39例胃肠道间质瘤的病理诊断与临床分析  

Clinical and Pathological Features of Gastrointestinal Stromal Tumor(GIST):a 39 Cases Report

作　　者：熊丽萍[1] 吴焕明[2] 陈寿松[1] 

机构地区：[1]广州军区武汉总医院病理科,武汉430070 [2]华中科技大学同济医学院病理教研室,武汉430030

出　　处：《中西医结合研究》2009年第3期140-142,共3页Research of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨胃肠道间质瘤(GIST)的临床病理、免疫组化特点及危险度参考指标,分析其在临床预后评估中的价值。方法观察39例GIST的病理形态特征,完成肿瘤性质初步判定,采用免疫组化方法检测分析CD117、CD34、SMA及S-100的表达水平,最终确定GIST的临床病理诊断性质、特征、组织来源以及良恶性。结果免疫组化染色显示CD117呈弥漫强阳性,CD34多呈弥漫强阳性,SMA及S-100偶呈局灶或散在阳性,阳性率分别为100%、81%、20%和16%。确诊该组39例GIST,其中可能良性5例,潜在恶性10例,恶性24例。结论免疫组化测定是GIST病理诊断的重要依据,CD117是诊断GIST的敏感而特异性的标志物。肿瘤病理判定与患者预后密切相关。Objective To explore the criteria of pathologic diagnosis for gastrointestinal stromal tumors （GIST）and the reference parameters for malignancy,and to evaluate the clinical prognosis. Methods The expression levels of CD117,CD34,SMA and S-100 were detected by immunohistochemical method and their morphologic characteristics were analyzed by Light microscopy. Results The immunohistochemical results showed that CDl17 were diffusely strongly expressed in all of GIST;CD34 also diffusely strongly in most of GIST;SMA and S-100 incidentally in some focus. Their positive rates were 100 %, 81 %, 20% and 16 % respectively. 5 benign cases, 10 potential malignancy cases and 24 malignant cases were finally diagnosed. Conclusion The pathologic diagnosis of GIST should he made based on the immunohistochemical staining results. CD117 was a sensitive and specific marker for diagnosing GIST. The prognosis was closely related to the degree of pathologic malignancy.

关 键 词：胃肠道 间质瘤 抗原CD117 CD34 

分 类 号：R735[医药卫生—肿瘤]