ezrin和VEGF在乳腺癌组织中的表达及意义  

The Expressions of ezrin and VEGF Proteins in Breast Cancer and Their Clinical Significance

作　　者：颜海[1] 李文广[1] 张燕妮[1] 凌黎[1] 李京微 姜海英[1] 李艳芳[1] 

机构地区：[1]徐州市第三人民医院肿瘤内科,江苏徐州221005

出　　处：《肿瘤基础与临床》2009年第3期198-200,共3页journal of basic and clinical oncology

基　　金：徐州市科技计划(编号XZ2006240)

摘　　要：目的研究乳腺癌组织中ezrin和VEGF蛋白表达与乳腺癌临床因素和预后的关系。方法应用免疫组化S-P法,检测63例癌组织,20例癌旁组织,30例乳腺良性肿瘤中ezrin和VEGF的表达情况。结果ezrin和VEGF在乳腺良性肿瘤和乳腺癌癌旁组织中均无异常表达。在乳腺癌组织中,ezrin和VEGF的异常表达率分别为55.56%(35/63)和65.08%(41/63),ezrin和VEGF在乳腺癌中的表达,与其淋巴结转移、临床分期呈正相关,而与无病生存时间呈负相关(P<0.001)。ezrin和VEGF在乳腺癌中的表达,与年龄、肿块大小以及月经情况无相关性(P>0.05)。结论检测ezrin和VEGF在乳腺癌中的表达,有助于判断乳腺癌的转移潜能和预后,ezrin可作为乳腺癌淋巴结转移以及判断乳腺癌预后的新指标。Objective To study the expressions and clinical significance of ezrin and VEGF in breast cancer, and to evaluate its relationship with lymph node metastasis, clinical stage and prognosis. Methods Immunohistochemical staining（S-P） was used to detect the expressions of ezrin and VEGF in 63 cases with breast cancer, 20 cases with corresponding adjacent tissues and 30 cases with benign tumors. The corre- lation of their expressions with relevant clinical data was statistically analyzed. Results The abnormal expression rates of ezrin and VEGF in benign tumors and corresponding adjacent tissues were negative. In 63 cases with breast cancer, the abnormal expression rates of ezrin and VEGF were 55.56% （35/63） and 65.08% （41/63）, respectively. The expressions of ezrin and VEGF were positively correlated with lymph node metastasis, clinical stage and negatively correlated with DFS （ P 〈 0.05 ） , but had no statistical relationship with tumor size, age and menopausal status（P 〉 0.05）. Conclusion The test of ezrin and VEGF expressions may have significant prognostic value assessing the de- grees of malignancy and potential lymph node metastasis probability of breast cancer. Ezrin may become a new target in evaluation of tumor prognosis.

关 键 词：EZRIN VEGF 乳腺癌 免疫组化 预后 

分 类 号：R737.9[医药卫生—肿瘤]