贲门癌组织中淋巴管密度的检测及其临床意义  

Lymphatic Vessel Density in Gastric Cardia Carcinoma and Its Clinical Significance

作　　者：周博[1] 冯笑山[1] 王公平[1] 高社干[1] 张广平[1] 马志坤[1] 郝曙光[1] 侯建峰[1] 茹艺[1] 陈强[1] 

机构地区：[1]河南科技大学第一附属医院肿瘤科,河南科技大学肿瘤研究所,河南洛阳471003

出　　处：《肿瘤基础与临床》2009年第3期239-241,共3页journal of basic and clinical oncology

摘　　要：目的观察贲门癌组织中淋巴管的分布及密度,并探讨其临床意义。方法应用D2-40单克隆抗体通过免疫组化Elivision法检测42例贲门癌手术标本和10例正常贲门黏膜中的淋巴管密度(LVD)。结果贲门癌周边区的LVD显著高于癌中心区及正常黏膜(P<0.05);癌中心区和正常黏膜的LVD差异无统计学意义(P>0.05);癌周边区LVD与肿瘤的淋巴结转移情况差异有统计学意义(P<0.05);癌周边区LVD与患者的性别、年龄、病理类型、肿瘤分化程度以及浸润深度无关(P>0.05);癌中心区LVD与上述病理指标均无关(P>0.05)。结论检测贲门癌组织LVD对了解贲门癌患者病情进展和预后判断具有一定临床意义。Objective To investigate the lymphatic vessel density（LVD） in gastric cardia carcinoma（GCC） and evaluate its clinical signifi- cance. Methods The lymphatic vessel density was detected using immunohistocbemical Elivision method with the D2-40 monoclonal anti- body in 42 cases with gastric cardia carcinoma samples and 10 cases with normal cardiac mucosa tissues. Results The LVD of peritumour region is higher than that of intratumour region and normal mucosa＂ tissues（P 〈 0. 05）. There was no difference between the intratumour re- gion and normal mucosa tissues （P 〉 0. 05）. The LVD of the peritumour region was positive correlated with the lymphatic metastasis （P 〈 0. 05）. There was no correlation between the LVD of the peritumour region and the age, sex, the histological types, the grades of carcinoma differentiation and the depth of carcinoma invasion （P 〉 0.05）. There was no correlation between the LVD of the intratumour region and the clinical pathological parameter （P 〉 0. 05）. Conclusion The LVD of the peritumour region might be an important marker for reflecting the progress and prognosis of GCC.

关 键 词：贲门癌 淋巴管密度 D2-40单克隆抗体 免疫组化Elivision法 

分 类 号：R735.1[医药卫生—肿瘤]