唑来膦酸及依班膦酸钠治疗恶性肿瘤骨转移疼痛的临床疗效观察  

A Clinical Study of Zoledronic Acid and Ibandronate in Treatment of Pain Caused by Metastatic Bone Tumors

作　　者：袁蕾蕾[1] 

机构地区：[1]济宁市第一人民医院肿瘤内科,山东济宁272100

出　　处：《肿瘤基础与临床》2009年第3期252-254,共3页journal of basic and clinical oncology

摘　　要：目的评价唑来膦酸及依班膦酸钠治疗恶性肿瘤引起骨疼痛的有效性和安全性。方法入选恶性肿瘤骨转移疼痛60例,随机分为两组,一组给予唑来膦酸注射液4mg,静脉滴注15min;另一组给予依班膦酸钠注射液4mg,静脉滴注3h。采用平行对照研究方法,每组用药3～6个周期。观察止痛起效时间、临床获益及毒副反应。结果唑来膦酸组和依班膦酸组用药后止痛有效率分别为75.02%和72.10%,差异无统计学意义(P>0.05);用药后中位起效时间分别为第5天和第7天,差异无统计学意义(P>0.05);两组用药后7d,ECOG评分改善,差异无统计学意义(P>0.05)。结论唑来膦酸及依班膦酸钠均能改善恶性肿瘤患者骨转移疼痛,显著改善生活质量,且毒副反应均可耐受。Objective To evaluate the efficacy and safety of zoledronic acid and ibandronate for the pain caused by metastatic turner of bone. Methods 60 patients with metastatic tumor of bone were randomly divided into two groups to receive either zoledronic acid or ibandronate for 2 to 4 cycles. Results The effective rates in the zoledronic acid group and the ibandronate group were 75.02% and 72.10%. No signif- icant difference was observed between the two groups. The median relief onset time was days 5 and days 7, respectively, and no significant difference was observed. There were differences in all the patients before and after medication, but there were no differences in the two groups. Conclusion The both zoledronic acid and ibandronate are efficient in the treatment of pain caused by metastatic tumor of bone, and the life quality of patients is improved. The adverse effect of both is light, and all have good tolerance.

关 键 词：唑来膦酸 依班膦酸钠 骨转移瘤 骨疼痛 

分 类 号：R730.59[医药卫生—肿瘤] R730.6[医药卫生—临床医学]