Synthesis of 6-sulfamoyl-4-oxoquinoline-3-carboxylic acid derivatives as integrase antagonists with anti-HIV activity  

作　　者：Zai Gang Luo Cheng Chu Zeng Lei Fu Yang Hong Qiu He Cun Xin Wang Li Ming Hu 

机构地区：[1]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China

出　　处：《Chinese Chemical Letters》2009年第7期789-792,共4页中国化学快报（英文版）

基　　金：the financial supports of the National Basic Research Program(No.2009CB930200);the Fund from Beijing City Education Committee(No.KM200610005029);Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality.

摘　　要：A series of novel 6-sulfamoyl-4-oxoquinoline-3-carboxylic acids derivatives have been synthesized and screened for HIV integrase inhibition activity. Their structures were confirmed by ESI-MS, ^1H NMR and ^13C NMR. 2009 Li Ming Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.A series of novel 6-sulfamoyl-4-oxoquinoline-3-carboxylic acids derivatives have been synthesized and screened for HIV integrase inhibition activity. Their structures were confirmed by ESI-MS, ^1H NMR and ^13C NMR. 2009 Li Ming Hu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关 键 词：QUINOLINE INTEGRASE Anti-HIV-1 activity 

分 类 号：TQ630.49[化学工程—精细化工] TQ463.24