单壁碳纳米管对小鼠肝和肾氧化损伤的诱导  

Induction of oxidative stress by single wall carbon nanotubes in the liver and kidney of mice

作　　者：王红蕾[1] 柯砚[1] 赵明明 吴凯[1] 杨旭[1] 

机构地区：[1]华中师范大学生命科学学院环境科学实验室,武汉430079

出　　处：《环境科学学报》2009年第7期1491-1495,共5页Acta Scientiae Circumstantiae

基　　金：国家自然基金面上项目(No.30570799)~~

摘　　要：为了评价单壁碳纳米管(SWCNTs)对生物体的毒性效应,以昆明小鼠为受试动物,采用腹腔注射的染毒方法,研究了SWCNTs和标准碳黑(CB)对其肝和肾组织氧化损伤的诱导.实验结果表明:与对照组相比,SWCNTs和CB暴露显著的降低了小鼠肝和肾中还原性谷胱甘肽(GSH)的含量、抑制了超氧化物歧化酶(SOD)的活力、诱导了脂质过氧化终产物丙二醛(MDA)的产生、提高了DNA-蛋白质交联率(DNA-protein crosslinks,DPC),但在最高浓度(0.08mg.d-1)暴露下,SWCNTs暴露组的影响程度要高于标准碳黑组.说明了SWCNTs暴露可以抑制小鼠肝和肾组织抗氧化系统,从而导致了器官的氧化损伤.并且这种氧化损伤的诱导部分是由于SWCNTs的特殊结构和金属元素的参与.In order to assess the toxic effects of single wail carbon nanotubes （SWCNTs） on organisms, in the present study, we investigated the induction of oxidative stress by SWCNTs or carbon black （CB） in liver and kidney using a mouse model. The results show that SWCNTs or CB exposure significantly decreased glutathione （GSH） content, superoxide dismutase （SOD） activity and increased the contents of final product of the lipid peroxidization MDA, as well as DNA-protein crosslinks （DPC） in the liver and kidney of mice. But the degree of stress in the SWCNTs exposure groups was higher than those in CB treated groups at the highest concentration （0.08 mg·d^-1）. Overall, this study demonstrates that SWCNTs exposure can produce oxidative stress in the liver and kidney of mice, and the induction of oxidative stress is partly due to SWCNTs＇ unique structure and metal participation.

关 键 词：单壁碳纳米管(SWCNTs) 碳黑(CB) 小鼠 氧化损伤 

分 类 号：X171.5[环境科学与工程—环境科学]