珠海地区妇女宫颈上皮内瘤变与高危型人乳头瘤病毒亚型关系的初步研究  

Preliminary study on relation of persistent high risk human papillomavirus infection to cervical intraepithelial neoplasia in Zhuhai region of Guangdong province

作　　者：姜星[1] 李敏[1] 

机构地区：[1]广东省珠海市妇幼保健院妇二科,广东珠海519000

出　　处：《中国肿瘤临床与康复》2009年第3期205-207,共3页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：广东省珠海市科技计划项目(PC20061099)

摘　　要：目的探讨珠海地区妇女宫颈上皮内瘤变与高危型人乳头瘤病毒亚型的关系。方法采用杂交捕获二代(HC-Ⅱ)方法定量检测珠海地区宫颈疾病患者HPV-DNA的含量,全部269例患者阴道镜下多点取活组织病理检查,根据病理学诊断结果分组。结果珠海地区高危型HPV在慢性宫颈炎、C INⅠ、C INⅡ及C INⅢ的感染率分别为13.5%、48.2%、73.8%及93.7%,HPV16在四组中感染率依次为3.6%、13.4%、47.6%及65.6%,宫颈病变存在多重HPV感染。结论珠海地区宫颈上皮内瘤变患者感染HPV16、18、31、58及35型较多见,多重HPV感染可能促进宫颈上皮内瘤变的发生。Objective To explore the relation of various HPV genotypes to cervical intraepithelial neoplasia （CIN） in Zhuhai region of Guangdong province. Methods HC-Ⅱ method was used to perform quantitative test for HPV-DNA in all patients receiving the gynaecological examination in our hospital. 269 women underwent cervical biopsy and were divided into four groups according to the histological diagnosis. Results 126 of 269 cases were HPV positive, accounting for 46. 8%. The HPV infection was found in 11 cases of cervicifis（13. 5% ） ,54 eases of CIN I （48. 2% ）, 31 cases of CIN II （73. 8% ） and 30 cases of CIN~[（93.7% ） in Zhuhai region of Guangdong province. The infection rates of HPV16 in the four groups were 3.6% ,13.4% ,47.6% and 65.6% respectively. Cervical lesion existed in multiple HPV infection. Conclusions The study shows that the infection of HPV16,18,31,58 and 35 often exists in women suffering from cervical intraepithelial neoplasia. The women with CIN may have multiple HPV infection.

关 键 词：高危型人乳头瘤病毒 宫颈上皮内瘤变 

分 类 号：R737.33[医药卫生—肿瘤] R730.2[医药卫生—临床医学]