CTHRC1和VEGF-C在直肠癌组织中的表达及相关性  

Expression and correlation between CTHRC1 and VEGF-C in human rectal carcinoma

作　　者：李靖涛[1] 赵洪川[2] 高春[1] 姚力[2] 陈少轩[2] 姚树坤[2] 

机构地区：[1]北京协和医学院研究生院,北京市100010 [2]卫生部北京中日友好医院,北京市100029

出　　处：《世界华人消化杂志》2009年第13期1318-1323,共6页World Chinese Journal of Digestology

摘　　要：目的:探讨血管内皮生长因子(VEGF-C)和胶原三股螺旋重复蛋白1(CTHRC1)在直肠癌组织中的表达特点及二者的相关性.方法:收集我院2004-10/2006-08手术切除的直肠癌病理标本98例,术前均未行任何治疗.采用免疫组织化学方法检测VEGF-C和CTHRC1的表达.分析他们的表达与患者年龄、性别以及直肠癌分化程度、临床分期及淋巴结转移的关系.结果:VEGF-C主要分布于肿瘤细胞中,其表达与直肠癌分化程度、临床分期及淋巴结转移密切相关(P<0.05);CTRHC1表达与直肠癌分化程度、临床分期密切相关(P<0.05),二者与直肠癌发生的年龄、性别无明显相关.此外,CTRHC1与VEGF-C的表达量呈正相关(r=0.629,P<0.001).结论:VEGF-C和CTHRC1在直肠癌侵袭转移中可能起重要作用,二者的表达可作为判定直肠癌生物学行为的参考指标.AIM： To study expression and correlation between CTHRC1 and VEGF-C in human rectal carcinoma. METHODS： Ninety-eight patients diagnosed with rectal carcinoma at China-Japan Friendship Hospital from October 2004 to August 2008, were included in our study. No treatment was given before surgery and the specimens were collected after surgery. The expression of CTHRC1 and VEGF-C was examined by immunohistochemistry and the correlation with clini- cal characteristics was analyzed by SPSS10.0. RESULTS： VEGF-C was mainly located in the tumor cells, and its expression was statistically correlated with tumor differentiation, clinical stages and lymph metastasis （P 〈 0.05）. The expression of CTRHC1 was correlated with theclinical stages and tumor differentiation （P 〈 0.05）, both of the expressions had no correlation with the age or gender of patients. Moreover, a positive correlation was observed between VEGF-C and CTHRC1 by correlative analysis （r = 0.629, P 〈 0.001）. CONCLUSION： CTHRC1 and VEGF-C may play important roles in invasion and metastasis in human rectal carcinoma. The two biomarkers can be applied to assess the malignancy of rectal cancer.

关 键 词：胶原三股螺旋重复蛋白1 血管内皮生长因子 直肠癌 

分 类 号：R735.37[医药卫生—肿瘤] R735.7[医药卫生—临床医学]