埃索美拉唑联合莫沙比利治疗老年低压型LES食管运动功能障碍29例  

Effect of esomeprazole and mosapride on the esophageal motility dysfunction in elderly patients with hypotensive LES: an analysis of 29 cases

作　　者：虞阳[1] 姚健凤[1] 夏俊[1] 赵尚敏[1] 于晓峰[1] 

机构地区：[1]华东医院消化内科,上海市200040

出　　处：《世界华人消化杂志》2009年第13期1359-1362,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨埃索美拉唑联合枸橼酸莫沙比利治疗老年低压型食管下括约肌(LES)食管运动功能障碍的作用.方法:采用随机对照法,将低压型LES并伴有食管蠕动功能异常的老年患者分为2组:治疗组29例,给予埃索美拉唑20mg,qd和枸橼酸莫沙比利5mg,tid,po;对照组28例给予枸橼酸莫沙比利5mg,tid,po.1mo后观察临床症状改善及LES压力和食管运动功能的改变,并观察有关不良反应的发生.结果:57例患者均完成研究,治疗组总有效率显著高于对照组总有效率(86.2%vs60.7%,P<0.01);治疗后,两组患者LES压较治疗前均明显升高(1.82±0.36vs1.09±0.18,1.91±0.45vs1.06±0.17,均P<0.001);治疗组食管运动功能改善率与对照组相比无统计学差异(48.3%vs53.6%,P=0.193).结论:联合应用埃索美拉唑和莫沙比利治疗老年低压型LES食管运动功能障碍性疾病安全有效.AIM： To investigate the therapeutic effect of esomeprazole and mosapride on aged hypotensive type LES dysfunction. esophageal motility METHODS： A total of 57 aged hypotensive type LES esophageal motility dysfunction patients were divided into treatment group （n = 29） and control group （n = 28）. Patients in treatment group were given esomeprazole 20 mg per day and mosapride 5 mg three times daily for I mo while patients in control group were given mosapride 5 mg three times daily for I mo. After medication treatment, the clinical symptoms, lower esophageal sphincter （LES） pressure and esophageal motility were observed. RESU LTS： Fifty seven cases of patients complet-ed the study. The total effective rate of treatment group was 86.2%, which was significantly higher than that of control group （60.7%）. LES pressure was improved significantly in both groups （1.82 ± 0.36 vs 1.09 ± 0.18, P 〈 0.001; 1.91 ± 0.45 vs 1.06 ± 0.17, P 〈 0.001, respectively）. Esophageal motility became better in both groups, but no statistical difference was observed between them after treatment（48.3% vs 53.6%, P = 0.193）. CONCLUSION： Esomeprazole and mosapride are effective for aged hypotensive type LES esophageal motility dysfunction.

关 键 词：食管运动功能障碍 老年 埃索美拉唑 莫沙比利 

分 类 号：R571[医药卫生—消化系统]