胃肠道间质瘤的诊治特点  

Diagnosis and Treatment of Gastrointestinal Stromal Tumors in 39 Patients

作　　者：赵楚雄[1] 洪楚原[1] 邓一文[1] 黄世章[2] 

机构地区：[1]广州医学院第二附属医院胃肠外科,广东广州510260 [2]广州医学院第二附属医院病理科,广东广州510260

出　　处：《广州医学院学报》2009年第1期40-43,共4页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨胃肠间质瘤(gastrointestinal stromal tumor,GIST)的临床特点、组织病理学和免疫组织化学特点及其治疗方法。方法:对本院胃肠外科2002年1月-2008年6月收治的39例G1ST患者的临床表现、手术处理、病理检查及免疫组织化学的特点进行回顾性分析。结果:39例均进行了手术治疗,GIST主要发生在胃20例(20/39,51.28%)和小肠12例(12/39,30.77%),其他部位少见。CD117阳性表达率为92.31%,CD34阳性表达率为82.05%。结论:GIST缺乏特征性临床表现,术前确诊率低,其确诊依赖病理检查,CD117和CD34对GIST具高度敏感性。GIST的治疗方法以手术切除为主。Objective： To explore clinical, histology and immunohistochemical characteristics of gastrointestinal stromal tumors （GIST）, and the therapy of GIST. Methods： The clinical manifestations, surgical treatments and pathologic examination findings of 39 Patients with gastrointestinal stromal tumors, who were hospitalized in our hospital from Feb 2002 to Jun 2008, were analyzed retrospectively. Results： surgical interventions were performed on 39 Patients with GIST, the tumor of 20 cases were originated in the stomach （51.28%） , of 12 cases were in small bowel （30.77%）, the others locations were rare. Positive ratio of CD117 and CD34 in the GIST were 92. 31% and 82.05%. Conclusion： The clinical situations of GIST have not specificity, so the ratio of preoperative definite diagnosis is low. The final diagnosis of GIST depends on pathological examination. CD117 and CD34 are sensitive markers for GIST,which plays an important role in the differential diagnosis of gastrointestinal Mesenehymal tumor. In present, surgical operation is the main method therapy to GIST.

关 键 词：胃肠道间质瘤 病理 免疫组织化学 手术/治疗 

分 类 号：R735[医药卫生—肿瘤] R734.2[医药卫生—临床医学]