胃肠道间质瘤患者预后多因素分析  

Multivariable analysis of prognosis in the GISTs patients

作　　者：卢明东[1] 张毅[1] 郑志强[1] 游涛[1] 俞耀军[1] 

机构地区：[1]温州医学院附属第二医院普外科,浙江温州325027

出　　处：《温州医学院学报》2009年第4期345-348,共4页Journal of Wenzhou Medical College

摘　　要：目的:探讨胃肠道间质瘤(GISTs)的临床病理特征和预后。方法:分析42例胃肠道间质瘤患者的临床病理资料和随访资料,免疫组化法检测CD117、CD34、VIM、S100和Ki67,分析各因素与预后的关系。结果:单因素分析显示:GISTs患者的预后与肿瘤大小、肿瘤部位、手术方式、Ki67标记指数和核分裂像均有关(P<0.05);多因素生存分析表明,细胞核分裂像和手术方式是GISTs预后的独立因素(P<0.05)。结论:手术方式的选择和核分裂像计数是影响预后的独立因素,但要准确判断其预后,我们要结合各临床病理因素综合考虑。Objective： To investigate the clinic and pathologic characteristics and prognostic factors of GISTs. Methods： The clinic and pathologic data of 42 patients with GIST were reviewed, and followed-up to study the correlation between clinic and pathologic characteristics and the prognosis. Results： Univariate analysis indicated that the tumor size, primary location, surgical modality, Ki67 expression and mitotic counts were significant predictors of survival （P〈0.05）. Multivariable survival analysis revealed that mitotic counts type and surgical modality were independent prognostic factors of GISTs （P〈0.05）. Conclusion： The mitotic counts type and surgical modality were significant prognostic factors in patients with GISTs. To evaluate the prognosis of GISTs, multiple parameters should be incorporated to reach an appropriate opinion on the prognosis of GISTs.

关 键 词：胃肠道间质瘤 免疫组织化学 多因素分析 预后 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]