长期服用抗精神病药物患者肝脏B超改变的对照研究  

Liver changes demonstrated by B-mode ultrasound in patients with long term treatment of antipsychotics

作　　者：蚁丽芬[1] 朱少毅[1] 

机构地区：[1]汕头大学医学院精神卫生中心,广东汕头515063

出　　处：《中国临床医学影像杂志》2009年第6期412-414,共3页Journal of China Clinic Medical Imaging

基　　金：广东省医学科学技术研究基金资助项目(A2006464)资助

摘　　要：目的:探讨长期服用抗精神病药物治疗精神分裂症患者肝脏改变的B超诊断。方法:对1255例单纯服用抗精神病药物超过2年的精神分裂症患者进行肝脏的B超检查,抽取服药5年以上者472例和服药5年以下者783例进行对照研究,行相关项目的比较。结果:长期服用抗精神病药物治疗的精神分裂症患者肝脏B超异常阳性率为28.05%,脂肪肝的发生率最高(24.70%),占该组异常阳性率的88.09%。异常阳性率因年龄、病程及服药时间的长短不同而具有显著性差异(P<0.05),年老(≥50岁)和病程及服药时间长(≥5年)者阳性率较高;性别和精神分裂症的类型不同肝脏B超异常阳性率差异无统计学意义(P>0.05)。结论:肝脏B超能明确显示长期服用抗精神病药物患者肝脏的改变,从而证实抗精神病药物对肝脏的损害。Objective： To study the liver changes in schizophrenic patients treated with long term antipsychoties by Bmode ultrasound. Methods： B-mode uhrasound examination was given to 1255 schizophrenic patients who had used antipsyehoties more than 2 years. In the 1255 patients, the first group contained 472 patients who had the treatment for more than 5 years, and the second gronp cnntained 783 patients who had the treatment less than 5 years, this group served as the control group. Related items were compared between the two groups. Results： In the first group, intake antipsychotics for more than 5 years, the liver abnormality detected by B-mode nhrasound was 28.05%, among which fatty liver is the most common abnormality, it accounts for 88.09% of all the ahnonualities in this group. The change of liver is related to age, course of the disease and the duration of administration of the antipsychoties. The positive rate of liver changes was higher in patients who were more than 50 years old; who had longer enurse of the disease and who had used medicine 5 years or longer than 5 years, but there were no statistical differences of sex and the type of schizophrenia. Conclusion： B-mode ultrasound can indi- cate clearly the lesions of liver in patients with long term taken antipsychotics.

关 键 词：精神分裂症 抗精神病药 肝疾病 超声检查 

分 类 号：R575[医药卫生—消化系统] R971.4[医药卫生—内科学]