中风病人急性期、慢性早期的BOLD-fMRI对比研究  

A comparative study of BOLD-fMRI between acute stage and early chronic stage of cerebral infarct

作　　者：胡涛[1] 黄穗乔[1] 钟镜连[1] 肖芳[1] 

机构地区：[1]中山大学第二附属医院放射科,广东广州510000

出　　处：《中国临床医学影像杂志》2009年第6期423-426,460,共5页Journal of China Clinic Medical Imaging

基　　金：广东省自然科学基金(课题编号7301383);广东省科技计划(项目编号2003c30614)资助项目

摘　　要：目的:探索脑中风后运动相关脑区激活的变化情况。方法:分析16例经临床和影像确诊的中风患者急性期和慢性早期的激活表现。结果:患手食指被动运动时主要激活对侧SM1区,其它非SM1区有时可见散在、微弱激活;纵向比较16例患者各运动相关脑区的激活体积、频率,其差异均无统计学意义(P>0.05),前后肌力差异亦无统计学意义(P>0.05);康复较好的患者,纵向比较肌力有升高(P<0.05),对侧SM1区的激活体积增大(P>0.05);对侧SM1区变化可有3种形式:激活体积增大、前后无变化及激活体积减小。结论:fMRI是一种有效的研究脑功能变化的成像方法。对侧SM1区是一个重要的运动脑区,其激活变化可以多样化。Objective： To investigate the cortical activation changes after stroke. Materials and Methods： BOLD-fMRI findings in 16 patients with cerebral infarction confirmed by clinical and imaging materials were analyzed. Results： The acti- vation of patients were mainly located in the contralateral SM1 and occasionally scattered in the non-SM1 cortex. There was no statistical significance in activation volumes, activation frequencies of cortex relative to movement by longitudinal compari- son between acute stage and early chronic stage. At the same time, the difference of grip strength of the two stages bad no statistical significance. For better rehabilitation patients, the grip strength was becoming higher （P〈O.05）, the activation volume was becoming bigger too （P〉0.05）. There were three forms of changes in the contralateral SMI： became larger, became smaller and no obvious changes. Conclusions： BOLD-fMRI is a good way for developing the changes of cortical activation. Both in acute and early chronic stage, the motor areas can be activated. The contralateral SM1 is an important motor area. The change forms of SMI were various.

关 键 词：脑血管意外 磁共振成像 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]