老年性痴呆患者尿中AD7c-NTP含量的研究  

AD7c-NTP level in urine of patients with Alzheimer′s disease

作　　者：闫鹏[1] 王蓉[2] 杜怡峰[1] 沈伦乾[1] 

机构地区：[1]山东大学附属省立医院神经内科,济南250021 [2]首都医科大学宣武医院神经内科,北京脑老化研究实验室,北京100053

出　　处：《山东大学学报（医学版）》2009年第6期106-108,117,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨尿中阿尔茨海默病相关的神经丝蛋白(AD7c-NTP)含量在老年性痴呆(AD)诊断中的价值。方法采用酶联免疫吸附测定法(ELISA),检测AD组(分轻、中、重3组)65例、血管性痴呆组(VaD组)60例、智能正常老年对照组120例尿液中AD7c-NTP含量,所有数据均经SPSS 13.0软件进行统计学处理。结果AD组、VaD组与智能正常老年对照组尿液中AD7c-NTP含量分别为(2.50±0.45)、(1.19±0.68)、(1.21±0.74)ng/mL,AD组明显高于另外两组,而VaD组与智能正常老年对照组差异无统计学意义(P>0.05);AD组内患者尿液AD7c-NTP含量与其痴呆程度呈正相关。结论尿液中AD7c-NTP含量在AD诊断和病情评估中有重要的临床参考价值。Objective To explore the value of urine AD7c-NTP assay in clinical diagnosis of Alzheimer＇s disease （AD）. Melthods The urine AD7c-NTP level was determined using Enzyme-linked immunosorbent assay in 245 elderly people, who were divided into three groups： the AD group（ n = 65）, the vascular dementia group （ VaD, n = 60） and the normal mental state group （ n = 120）. Statistical analysis was performed using SPSS 13.0. Results The urine AD7c-NTP content of the three groups were （2.50±0.45）ng/ml, （1.19 ± 0.68）ng/ml and （1.21 ± 0. 74） ng/ml. Compared with the normal mental state group and the VaD group, AD group had a significant increase of the urine ADTc-NTP level, which was positively correlated with the severity of the disease. No significant difference was found between the VaD group and the normal mental state group. Conclusion Urine AD7c-NTP level, probably a biochemical marker of AD, is of important and practical value in clinical diagnosis and condition assessment of AD.

关 键 词：阿尔茨海默病 痴呆 血管性 阿尔茨海默病相关的神经丝蛋白 酶联免疫吸附测定 尿 

分 类 号：R741.04[医药卫生—神经病学与精神病学]