Application of atomic force microscopy to living samples from cells to fresh tissues  

作　　者：CHEN PeiPei DONG HongTao CHEN Long SUN QuanMei HAN Dong 

机构地区：[1]National Center for Nanoscience and Technology, Beijing 100190, China [2]Mangya Public Security Bureau, Haixi Mongolian and Tibetan Autonomous Prefecture of Qinghai Province 816400, China

出　　处：《Chinese Science Bulletin》2009年第14期2410-2415,共6页

基　　金：Supported by the National Natural Science Foundation of China (Grant No. 90709054);National Basic Research Program of China (Grant Nos. 2005CB724700, 2006CB705600)

摘　　要：Atomic force microscopy is a novel method for imaging and characterization in biomedicine. However, high-resolution imaging of living samples from cells to tissues still remains a challenge. In this paper, two types of AFM working mode (contact mode and tapping mode) which are utilized for the imaging of living cells and tissues are discussed. A new magnetic tapping mode (MAC mode), which is more suitable for living samples, and a novel data collecting system named TREC, are also introduced.Atomic force microscopy is a novel method for imaging and characterization in biomedicine. However, high-resolution imaging of living samples from cells to tissues still remains a challenge. In this paper, two types of AFM working mode （contact mode and tapping mode） which are utilized for the imaging of living cells and tissues are discussed. A new magnetic tapping mode （MAC mode）, which is more suitable for living samples, and a novel data collecting system named TREC, are also introduced.

关 键 词：原子力显微镜 细胞组织 活细胞 显微镜观察 样本 应用 成像方法 轻敲模式 

分 类 号：S33[农业科学—作物遗传育种] TH742[农业科学—农艺学]