骨肉瘤组织中主要组织相容性复合物Ⅰ类链相关A蛋白和基质金属蛋白酶-9的关系  

Relationship between Major Histocompatibility Complex Class Ⅰ Chain-related A and Matrix Metalloproteinase-9 in Osteosarcoma Tissue

作　　者：卢善明[1,2] 薛玲[3] 邓汪东[4] 曹清华[3] 车丽洪[3] 

机构地区：[1]东莞市人民医院病理科,广东东莞523018 [2]汕头大学医学院第一附属医院病理科,广东汕头515041 [3]中山大学附属第一医院病理科,广东广州510080 [4]汕头大学医学院第一附属医院泌尿外科,广东汕头515041

出　　处：《汕头大学医学院学报》2009年第2期86-88,F0002,共4页Journal of Shantou University Medical College

基　　金：国家自然科学基金面上资助项目(30300354)

摘　　要：目的:探讨骨肉瘤组织中主要组织相容性复合物Ⅰ类链相关A(MICA)蛋白和基质金属蛋白酶-9(MMP-9)的关系。方法:用免疫组化检测66例骨肉瘤组织中MICA和MMP-9蛋白的表达情况。结果:MICA和MMP-9蛋白在骨肉瘤组织的表达率分别为51.5%和54.5%,两者在骨肉瘤组织的表达呈正相关(r=0.414,P<0.01)。结论:MICA广泛表达于骨肉瘤组织,其与MMP-9表达可能由相同信号通路调控。Objective： To investigate the relationship between major histocompatibility complex class Ⅰ chain-related A （MICA）and matrix metalloproteinase-9（MMP-9）in osteosarcoma tissues. Methods： MICA and MMP-9 expressions were examined in osteosarcoma tissues（66 samples）by immunohistochemistry. Results： MICA and MMP-9 protein were detected in 51.5% and 54.5% of osteosarcoma tissues, respectively. MICA expression increased with the increase of MMP-9 expression（r =0.414, P 〈 0.01）. Conclusion： MICA is widely expressed in osteosarcoma tissues. The expression of MICA and MMP-9 may be regulated by the same signal transduction.

关 键 词：骨肉瘤 主要组织相容性复合物Ⅰ类链相关A蛋白 基质金属蛋白酶-9 

分 类 号：R738.1[医药卫生—肿瘤]