副肿瘤综合征相关的外周神经病变  

Peripheral Neuropathy Associated with Paraneoplastic Syndrome

作　　者：毕建波[1] 王俐滢[1] 曲忠森[1] 孙培军[1] 

机构地区：[1]潍坊医学院附属青岛市胶州中心医院,266300

出　　处：《职业与健康》2009年第13期1413-1414,共2页Occupation and Health

基　　金：中国博士后科学基金资助项目(20060390635)

摘　　要：肿瘤可以刺激机体产生神经抗体,使患者出现外周神经损害,可视作副肿瘤综合征的外周神经病变,包括感觉神经病变、运动神经病变、感觉运动神经病变、周围神经过度兴奋、自主神经病变、单神经炎、浆细胞增殖疾病的神经病变等,部分针对肿瘤的特异抗体,如:抗-Hu抗体、电压门控型钾通道抗体可以提示肿瘤的存在,进一步结合必要的电生理检测,其他的临床影像学及实验室检测对肿瘤的诊断和疗效的判定有积极意义。Tumors can stimulate body to produce nerve antibody, and induce peripheral nerve injuries. These injuries are considered as peripheral neuropathy associated to paraneoplastic syndrome, which including sensory neuronopathy, motor nearonopathy, sensory and motor neuronopathy, peripheral nerve hyperexcitability, autonomic neuropathy, mononeuritis and nerve complications of plasmacytosis,etc. Some specific antibodies such as anti-hu antibody, voltage-gated potassium channel antibody can indicate presence of tumors. These antibodies combined with electrophysiological examination, clinical imagine tests and laboratory detection are helpful for diagnosis of tumors and evaluating therapeutic effects.

关 键 词：副肿瘤综合征 外周神经 

分 类 号：R73[医药卫生—肿瘤]