原癌基因HER-2在乳腺癌组织中的表达及其临床意义  

Expression and clinical significance of protooncogene HER2 in breast cancer

作　　者：金哲洙[1] 许东哲[1] 

机构地区：[1]延边大学附属医院普通外科,吉林延吉133000

出　　处：《延边大学医学学报》2009年第2期117-119,共3页Journal of Medical Science Yanbian University

摘　　要：[目的]探讨原癌基因HER-2在乳腺癌组织中的表达及其临床意义.[方法]采用免疫组织化学法对74例乳腺癌标本中原癌基因HER-2进行测定,分析其表达情况与患者年龄、肿块大小、淋巴结转移、病理类型及复发转移的关系.[结果]浸润性乳腺癌组织中HER-2阳性表达率明显高于原位癌;腋淋巴结转移阳性者HER-2阳性表达率明显高于无转移者;复发转移者HER-2阳性表达率为100%.[结论]HER-2阳性表达可作为反映乳腺癌侵袭力及判断预后的指标.OBJECTIVE To investigate the expression and its clinical significance of protooncogene HER-2 in breast cancer. METHODS The expression of HER-2 was detected by immunohistochemistry assays in 74 cases of breast cancer, and it was retrospectively analyzed that the relationships between expression status and age, tumor size, metastasis of lymph nodes, pathological types and occurrence RESULTS The positive expression rate of HER-2 in invasive breast cancer was significantly higher than that in carcinoma in situ. The expression of HER-2 was the more higher positive in patients with axillary lymph node metastasis than in those without axillary lymph node metastasis. The positive expression rate of HER-2 was 100% in the patients with occurrence and matastasis. CONCLUSIONS The positive expression of HER-2 is one of index as reflecting the invasiveness of breast cancer and judgment of prognosis.

关 键 词：受体 erbB-2 乳腺肿瘤 癌 导管 乳腺 

分 类 号：R737.9[医药卫生—肿瘤] R730.21[医药卫生—临床医学]