p16^(INK4a)基因与子宫颈癌及其癌前病变关系的研究进展  

Study on The Relationship Between p16^(INK4a) and Cervical Cancer

作　　者：张彩霞[1] 段仙芝[1] 岑尧[1] 

机构地区：[1]内蒙古自治区医院妇产科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2009年第5期583-586,共4页Inner Mongolia Medical Journal

摘　　要：随着分子生物学技术的飞速发展,人们越来越认识到抑癌基因在肿瘤的发生发展过程中具有重要作用。p16INK4a是人们发现的第一个直接参与细胞周期调控的抑癌基因。它在宫颈癌和癌前病变阶段表现为过表达,可作为一种肿瘤标志物用于宫颈癌及癌前病变的临床筛查及诊断中。With the development of molecular biology, it is knowed that anti - ongene played important role in the genesis and development of tumors, p16^INK4a is the first known anti - oncogene involved in regulating cell cycle. It shows overexpression in cervical cancer and precancerous lesions, p16^INK4a may be used in clinical screening and diagnosis of cervical cancer and precancerous leisions.

关 键 词：p16INK4a宫颈癌 癌前病变 

分 类 号：R737.33[医药卫生—肿瘤]