新疆卡波西肉瘤组织中MT1-MMP和ARHGDIB蛋白的表达  

Expression of MT1-MMP and ARHGDIB in Kaposi's Sarcoma Tissue in Xinjiang

作　　者：罗先道 郭淑丽 杨磊[1,2] 曾妍 赵瑾[3] 

机构地区：[1]新疆地方病与民族高发病重点实验室-生化教研室,新疆石河子832002 [2]杭州师范大学医药卫生管理学院,浙江杭州310036 [3]石河子大学医学院,新疆石河子832002

出　　处：《现代生物医学进展》2009年第12期2222-2224,共3页Progress in Modern Biomedicine

基　　金：国际科技合作重点项目(No.2005DFA30780);教育部科学研究重大项目(No.206166)

摘　　要：目的:探讨新疆卡波氏肉瘤组织中膜型1型基质金属蛋白酶(Menberane 1 Matrix metalloproteinases,MT1-MMP),Rho蛋白解离抑制因子β(Rho GDP dissociation inhibitor GDI beta,ARHGDIB)的表达及临床意义。方法:应用免疫组织化学Envision二步法检测新疆17例卡波氏肉瘤和17例健康人正常皮肤组织内MT1-MMP和ARHGDIB的表达水平。结果:免疫组化显示MT1-MMP和ARHGDIB在卡波氏肉瘤组织阳性表达率为82.4%和100%,在正常皮肤组织中阳性率为6.9%和17.7%,差异均有统计学意义(P<0.01)。结论:新疆卡波西肉瘤组织中MT1-MMP和ARHGDIB蛋白呈异常表达,有可能在KS的发展过程中发挥了重要作用。Objective： To explore the expression of Menberane 1 Matrix metalloproteinases （MT1-MMP） and Rho GDP dissocia- tion inhibitor GDI beta （ARHGDIB） in kaposi＇s sarcoma （KS） in Xinjiang and its clinical significance. Methods： Immunohistochemical envision technique was used to detect MT1-MMP and ARHGDIB expression in KS tissue （n=17） and normal skin tissues （n=17） from healthy persons. Results： The positive expression rate of MT1-MMP was 82.4% in KS tissue, and 6.9% in normal skin tissues; while the positive expression of ARHGD1B was 100% in KS tissue, and 17.7% in normal skin tissues, with significant differences （P〈0.01）. Con- elusions： Both of MT1-MMP and ARHGDIB express abnormally in KS tissues, which maybe play an important role in the development of KS in Xinjiang.

关 键 词：卡波氏肉瘤 MT1-MMP ARHGDIB 免疫组织化学 

分 类 号：R361.2[医药卫生—病理学]