COX-2、VEGF-C的表达与喉鳞癌临床病理特征的关系  

COX-2,VEGF-C Expression and Its Relationship with Clinicopathological Parameters in Human Laryngeal Squamous Carcinoma

作　　者：姚鸿超[1] 肖辉[1] 赵广鑫 唐海燕[3] 刘鸣[1] 

机构地区：[1]哈尔滨医科大学附属第二医院耳鼻咽喉-头颈外科,黑龙江哈尔滨150086 [2]呼兰第一人民医院耳鼻咽喉科,黑龙江哈尔滨150500 [3]海伦市人民医院耳鼻咽喉科,黑龙江海伦152300

出　　处：《现代生物医学进展》2009年第12期2281-2283,2318,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生厅医学科研课题(2005-283)

摘　　要：目的:通过检测喉鳞癌组织中COX-2和VEGF-C的表达情况,探讨其与喉癌各临床病理特征的关系。方法:免疫组化S-P方法检测64例喉鳞癌及33例正常喉粘膜组织中COX-2和VEGF-C的表达,分析二者相关关系,并分析其与喉癌临床各参数的相关性。结果:在喉鳞癌组织中COX-2和VEGF-C的表达较高,其阳性率分别为76.56%、96.77%,与正常喉粘膜中9.09%、3.03%相比差异均具有显著性意义(P<0.01)。COX-2和VEGF-C在声门上型、分化程度低以及晚期喉癌中表达阳性率高(分别为57.58%、96.77%、83.67%和79.07%、90.32%、100%),而在其他类型中表达低,差异具有显著性意义(P<0.01),COX-2和VEGF-C表达呈正相关。结论:COX-2、VEGF-C的高表达与喉鳞癌的临床密切相关,其对于喉癌的淋巴转移及预后均有重要意义。Objective： To detect the expression of COX-2 and VEGF-C, and to investigate their relationship with clinicopathological parameters in human laryngeal squamous carcinoma （LSCC）. Methods： Immunohistoehemieal S-P method was used to measure the level of COX-2 and VEGF - C protein in 64 samples of human LSCC and 33 samples of normal laryngeal mucosa, analyzing their rela- tionship with clinicopathological parameters. Results： The expression of COX-2 and VEGF-2 was higher in LSCC, their positive rates were 76.56%,96.77% respectively, but in normal laryngeal mueosa were 9.09%, 3.03%, there was statistical difference in both groups （P〈0.01）. The expression of COX-2 and VEGF-2 was higher in upglottis, poorly-differentiated and III and IV stages LSCC （57.58%, 96.77%, 83.67% and 79.07%, 90.32%, 100%）, but lower in others types, there was statistical difference in both groups（P〈0.01 ）. The ex- pression of VEGF-C was related with COX-2. Conclusions： Higher expression of COX-2 and VEGF-C was closely eorrelated with LSCC ,which is of significance for lymphatic metastasis and prognosis.

关 键 词：环氧化酶-2 血管内皮生长因子-C 喉肿瘤 癌 鳞状 

分 类 号：R739.63[医药卫生—肿瘤]