Expression of IL-1α, IL-6, TGF-β, FasL and ZNF265 During Sertoli Cell Infection by Ureaplasma Urealyticum  

作　　者：Rongping Li Yebin Xi Xiuzhi Liu Guangjie Chen Baoguo Wang Lihua Jiang Weiyi Li 

机构地区：[1]Shanghai Jiao Tong University School of Medicine, Department of ImmunoLogy, Shanghai Institute of Immunology, Shanghai 200025, China

出　　处：《Cellular & Molecular Immunology》2009年第3期215-221,共7页中国免疫学杂志（英文版）

基　　金：This study was financially supported by the key innovative project of the ShangHai educational committee （No. 09ZZ117） and Shanghai institute of Immunology Science Foundation （No. 08A05） We thank Professor Ping Xu （Institute of Life Science, Fu Dan University） for the gift of primary antibody, rabbit anti-rat ZNF265.

摘　　要：To investigate immunoregulatory mechanisms of Sertoli cells in the testis in vitro and in vivo, we utilized our well-characterized Ureaplasma Urealyticum （UU）-induced model. We investigated the expressions of IL-1α, IL-6, TGF-β, FasL and ZNF265 at the first, second and third weeks post-infection. During recovery from inflammation and with the help of negative regulators TGF-β and FasL, the high levels of IL-1α and IL-6 expressions were observed in the early stages of the infection, and decreased gradually in the later weeks both in vitro and in vivo. The trend of varied expression of ZNF265 was similar to those of TGF-β and FasL in vitro and in vivo for Sertoli cells infected with UU.To investigate immunoregulatory mechanisms of Sertoli cells in the testis in vitro and in vivo, we utilized our well-characterized Ureaplasma Urealyticum （UU）-induced model. We investigated the expressions of IL-1α, IL-6, TGF-β, FasL and ZNF265 at the first, second and third weeks post-infection. During recovery from inflammation and with the help of negative regulators TGF-β and FasL, the high levels of IL-1α and IL-6 expressions were observed in the early stages of the infection, and decreased gradually in the later weeks both in vitro and in vivo. The trend of varied expression of ZNF265 was similar to those of TGF-β and FasL in vitro and in vivo for Sertoli cells infected with UU.

关 键 词：ZNF265 TGF-Β FASL Sertoli cell IMMUNOREGULATION 

分 类 号：Q786[生物学—分子生物学] Q516