血管内皮生长因子阳性表达与非小细胞肺癌临床特征的关系  

Effect of VEGF on the progression and prognosis in non-small cell lung cancer

作　　者：穆海玉[1] 沈春燕[1] 陶盟[1] 

机构地区：[1]天津武警医学院附属医院肿瘤中心,天津300162

出　　处：《现代肿瘤医学》2009年第7期1259-1261,共3页Journal of Modern Oncology

摘　　要：目的:研究血管内皮生长因子(vascular endothelial growth factor VEGF)在非小细胞肺癌的阳性表达、影响肺癌进展和预后的作用机制。方法:应用免疫组化SABC染色法检测40例原发性支气管肺癌标本中VEGF的阳性表达、微血管密度(microvessel density,MVD)计数,评价VEGF和MVD的关系、VEGF与非小细胞肺癌临床病理参数之间的关系。结果:VEGF在非小细胞肺癌组织中呈现阳性高表达,其含量及阳性表达与肿瘤大小和淋巴结转移密切相关。肿瘤直径越大、已有淋巴结转移,则VEGF含量和表达越高。在VEGF表达阳性的癌组织中MVD值明显高于VEGF阴性表达的肺癌组织,差异具有统计学意义。结论:VEGF通过调节和诱导肺癌微血管的生成而促进非小细胞肺癌的发展,可作为评估非小细胞肺癌恶性程度、淋巴结转移潜能和预后的重要监测指标之一。Objective：To study the vascular endothelial growth factor （VEGF） positive expression and the relationship between the VEGF and the prognosis in non - small cell lung cancer （NSCLC）. Methods： VEGF expression was detected by immuno - histochemistry in 40 NSCLC Patients. Results ： the VEGF positive expression was mainly located in the cytoplasm of lung cancer. The positive rate of VEGF in non - small cell lung cancer was significantly higher than that in non - lung cancer. The more late stage is, and the more extensive metastasis of non small cell lung cancer is, the higher VEGF positive expression is. MVD was notably higher in the tissue specimens with VEGF positive expression. Conclusion： VEGF plays an important role in the process of growth and metastasis of non - small cell lung cancer.

关 键 词：非小细胞肺癌 血管内皮生长因子 微血管密度 血管生成 

分 类 号：R730.3[医药卫生—肿瘤] R734.2[医药卫生—临床医学]