The Molecular Mechanisms of Nm23-H1 Gene Transfection on Reversing Invasion and Metastasis Phenotype in Human High-metastataic Large Cell Lung Cancer Cell Line L9981  

作　　者：Qinghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China

出　　处：《中国肺癌杂志》2009年第6期I0009-I0011,共3页Chinese Journal of Lung Cancer

基　　金：supported by the grants from the Key Project of National Natural Science Foundation of China (No.30430300 , to Qinghua ZHOU);Key Projects of Tianjin Sci-Tech Support Program (No. 07SY-SYSF05000 and No. 06YFSZSF05300, to Qinghua ZHOU)

摘　　要：Background: Our previous studies have proved that nm23-H1 gene was a tumor metastatic suppressive gene, tumor metastasis phenotype of human lung cancer could be reversed by transfection of nm23-H1 cDNA, butBackground： Our previous studies have proved that nm23-H1 gene was a tumor metastatic suppressive gene, tumor metastasis phenotype of human lung cancer could be reversed by transfection of nm23-H1 cDNA, but the molecular mechanism ofnm23-H1 for inhibiting tumor invasion and metastasis is unclear. ＂Ihe aim of this study is to explore the molecular mechanism of nm23-Hl reversing the invasion and metastasis phenotype in human high-metastatic large cell lung cancer line L9981.

关 键 词：癌细胞转移 肺癌 临床 治疗 

分 类 号：R734.2[医药卫生—肿瘤]