Alterations in the Cytoskeleton and Biological Behavior in Human Lung Cancer Cell Line L9981 by Nm23-H1 gene Transfection  

作　　者：Zhe WANG Junke FU Zhihao WU Hongyu LIU Jun CHEN Liya SUN Q inghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Mieroenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University Hospital, Tianjin 300052, China [2]Department of Thoracic Surgery, The 1^st University Hospital, Xi'An Medical University, XfAn, China

出　　处：《中国肺癌杂志》2009年第6期475-476,共2页Chinese Journal of Lung Cancer

基　　金：supported by the grants from the Key Project of National Natural Science Foundation of China (No .30430300 , to Qinghua ZHOU);Key Projects of Tian-jin Sci-Tech Support Program (No . 07SY SY SF05000 and No 06YFSZSF05300, to Qinghua ZHOU)

摘　　要：Objective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been knownObjective and Methods The key cause of failure to cure and high mortality in lung cancer. At present, it has been known that lung cancer metastasis was controlled by many genes, especially the tumor metastatic suppressive gene. nm23 gene was discovered in 1988 as a first and the most important tumor metastatic suppressive gene. It has been proved that a close correlation existed between the high metastatic rate and the low expression or alleic deletion ofnm23-H1 gene by DNA, mRNA and protein levels in lung cancer, The lung cancer with nm23-H1 gene deletion is always combined with abnormal expression of some other metastastic-related genes. Dr. Zhou Qinghua has hypothesized that nm23-H1 gene may be an upstpeam regulatory gene of metastatic-related genes and it can regulate the downstream genes to inhibit metastasis. In order to explore the effect of nrn23-H1 gene on cytoskeleton and biological behavior of human lung cancer and the molecular mechanisms regulating the cytoskeleton of lung cancer cell,

关 键 词：肺癌 治疗 诊断 疗效 

分 类 号：R734.2[医药卫生—肿瘤]