Alteration of Gene Expression Profile and Signal Pathway Induced by Methylseleninic Acid in Human Lung Cancer Cell Lines  

作　　者：Ting WANG Zhihao WU Hongyu LIU Jun CHEN Liya SUN Qjnghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute Tianjin Medical University Hospital, Tianjin 300052, China

出　　处：《中国肺癌杂志》2009年第6期476-477,共2页Chinese Journal of Lung Cancer

基　　金：supported by the grants from the Key Project of National Natural Science Foundation of China (No.30430300 , to Qinghua ZHOU);Key Projects of Tianjin Sci-Tech Support Program (No. 07SYSYSF05000 and No. 06YF-SZSF05300, to Qinghua ZHOU)

摘　　要：Objective and Methods Lung cancer has a fastest growing rate of morbidity and mortality among malignant tumors and poses a great threat to the human health. Chemotherapy, as oneObjective and Methods Lung cancer has a fastest growing rate of morbidity and mortality among malignant tumors and poses a great threat to the human health. Chemotherapy, as one of three major therapies, plays an important role in the treatment of lung cancer. However, a therapeutic plateau has been reached with classical cytotoxic drugs. Therafore, research and development of natural anti-lung cancer drug with minimal toxicity and maximal efficacy represents an urgent topic and frostline in developing anti-cancer drugs. Current researches showed that methylselenium acid （MSA） could inhibit proliferation and induce apoptosis of a wide range of tumors such as prostate cancer and breast cancer. Our recent studies indicated that MSA could markedly inhibit proliferation and induce apoptosis of L9981 cell line, a human high metastasis large cell lung cancer cell line, A great line of evidences suggested that the proliferation-inhibiting and apoptosis-inducing effects of MSA are associated with the cell cycle arrest and activation of apoptosis-related pathways, and the underlying mechanisms vary in different tumor cells.

关 键 词：肺癌 治疗 疗效 临床 

分 类 号：R734.2[医药卫生—肿瘤]