Changes of the Proteomic Profiles in Human High-metastatic Large Cell Lung Cancer Cell Line L9981 by Transfecting with nm23-H1 Gene  

作　　者：Youlin DENG Wen ZHU Sen WEI Gang CHEN Zhigang LI Jun CHEN Hongyy LIU Zhihao WU Ke XU Ojnghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University Hospital, Tianjin 3000S2 China [2]The Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China

出　　处：《中国肺癌杂志》2009年第6期479-480,共2页Chinese Journal of Lung Cancer

基　　金：supported by the grants from the National Natural Science Foundation of China;Science Foundation of Sichuan University (No. 30070333 and No.200349)

摘　　要：Background and Objective Cancer metastasis is not only the malignant characteristics of lung cancer, but also the key cause of failure to cure and high mortality. It has been provedBackground and Objective Cancer metastasis is not only the malignant characteristics of lung cancer, but also the key cause of failure to cure and high mortality. It has been proved that lung cancer metastasis is a complex process involving multiple gene and steps. Study on lung cancer metastasis has been focused on molecular pathogenesis for a long time, and outcomes are achieved in gene （DNA） and transcription （mRNA） level. Nm23 gene discovered in recent years is considered as one of the most important tumor metastatic suppressive gene. It has been proved that a close correlation exists between the high metastatic rate and the low expression or alleic deletion of nm23-H1 gene at DNA, mRNA level. But little is known about the molecular mechanism of metastasis suppression by nm23-H1 and the change of protein expression. By the limitation of itself, genomics cannot explain the interaction between proteins or between proteins and other bio-molecules, so the emphasis is gradually shifting to proteome recently. The aims of this study are to explore what effects will be achieved after transfection ofnrn23-Hl gene into human high-metastatic large cell lung cancer cell line L9981 for proteome, what difference of proteome will be existd comparing the human high- and low-metastatic large cell lung cancer cell lines.

关 键 词：肺癌 治疗 疗效 临床 

分 类 号：R734.2[医药卫生—肿瘤]