The Molecular Mechanisms of Nm23-H1 Gene Transfection on Reversing Invasion and Metastasis Phenotype in Human High-metastataic Large Cell Lung Cancer Cell Line L9981  

作　　者：Qjnghua ZHOU 

机构地区：[1]Tianfin Key Laboratory oJ: Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University Hospitalj Tianfin 300052, China

出　　处：《中国肺癌杂志》2009年第6期482-482,共1页Chinese Journal of Lung Cancer

基　　金：supported by the grants from the Key Project of National Natural Science Foundation of China (No.30430300 , to Qinghua ZHOU);Key Projects of Tian-jin Sci-Tech Support Program (No. 07SYSYSF05000 and No. 06YFSZSF05300, to Qinghua ZHOU)

摘　　要：Background and Objective Our previous studies have proved that nm23-H1 gene was a tumor metastatic suppressive gene, tumor metastasis phenotype of human lung cancer couldBackground and Objective Our previous studies have proved that nm23-H1 gene was a tumor metastatic suppressive gene, tumor metastasis phenotype of human lung cancer could be reversed by transfection of nm23-H1 cDNA, but the molecular mechanism of nm23-H1 for inhibiting tumor invasion and metastasis is unclear. The aim of this study is to explore the molecular mechanism of nm23-H 1 reversing the invasion and metastasis phenotype in human high-metastatic large cell lung cancer line L9981.

关 键 词：Nm23-H1细胞 肺癌 癌细胞 治疗 疗效 

分 类 号：R734.2[医药卫生—肿瘤]