Transfection of Nm23-H1 Gene Inhibited the Metastatic Potential of Human High-metastatic Large Cell Lung Cancer L9981  

作　　者：Haixia ZHENG Zhilin SUN Yang QIN Wen ZHU Li REN Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Ke XU Qinghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Environment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, China [2]Department of Medical Oncology, Shenzhen Hospital, Cancer, Beijing University, Shenzhen, China [3]The Key Laboratory of Lung Cancer Molecular Biology of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, China

出　　处：《中国肺癌杂志》2009年第6期490-492,共3页Chinese Journal of Lung Cancer

基　　金：supported by grants from the Key Project of National Natural Science Foundation of China (to Qinghua ZHOU) (No.30430300);National Natural Science Foundation of China (to Qinghua ZHOU) (No.30070333)

摘　　要：Background and objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. Elucidating the molecular mechanism ofBackground and objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. Elucidating the molecular mechanism of tumor invasion and metastasis will provide new molecular targets for targeting terapy of lung cancer. Invasion and metastasis is complex multi-step process involving activation of tumor metastasis genes as well as inactivation of tumor metastasis suppressor genes. Nm23-HI gene is originally identified as a tumor metastasis suppressor gene whose alteration is demonstrated to be closely related to many malignant tumor metastases. The reduced expression and hetero-deletion ofnm23-H1 gene have been proved to be closely correlated with the high metastasis potential and poor prognosis of lung cancer. In addition, the abnormality of nm23-H1 gene is often companied with the changes of tumor metastasis-related genes. As a result, Dr. Odnghua Zhou from China hypothesized that there was a ＂Lung Cancer Metastatic Suppressive Cascade＂ in lung cancer and nm23-H1 might serve as an upstream regulatory gene to inhibit lung cancer metastasis by regulating downstream genes of this cascade.

关 键 词：NM23-H1 肺癌 临床 治疗 

分 类 号：R734.2[医药卫生—肿瘤]