The Effects of Intracellular Glutathione Content on the Sensitivity of Methylseleninic Acid to Human High-metastatic Large Cell Lung Cancer Cell Line L9981  

作　　者：Chengfei LIU Jun CHEN Liya SUN Yu ZHU Ting WANG Na-galakshmi NADIMINTY Allen C. GAO Qinghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University Hospital, Tianjin 300052, China [2]Department of Urology and Cancer Center, University of California Davis Medical Center, Sacramento, CA 958177, USA

出　　处：《中国肺癌杂志》2009年第6期510-511,共2页Chinese Journal of Lung Cancer

基　　金：supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30430300);National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30670922);INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)

摘　　要：Background and Objective Lung cancer has the fastest increasing rate of morbidity and mortality all over the world and appears to be one of the most dangerous malignant tumorsBackground and Objective Lung cancer has the fastest increasing rate of morbidity and mortality all over the world and appears to be one of the most dangerous malignant tumors that is threatening human being＇s health and lives, it also has the lowest cure rate on all tumors. Although operation is the first choice to the early stage lung cancer, but searching for new antilung cancer drugs, especially the one with maximal effiiency and minimal toxicities is necessary to cure the advanced lung cancer and prolong the patients＇ lives. Selenium has been well known as an antioxidant in the nutritional range of intake, in many human clinical trials. Supra-nutritional selenium supplement has been shown to reduce risk of cancers of several organs, including lung cancer, there still has several clinical ongoing trials to confirm the cancer chemopreventive effects of selenium.

关 键 词：肺癌 癌细胞 治疗 疗效 

分 类 号：R734.2[医药卫生—肿瘤]