Influence of Nm23-H1 Gene Site Mutagenesis on Invasive And Metastatic Phenotype in Human High-Metastatic Large Cell Lung Cancer Cell Line L9981  

作　　者：Daxing ZHU Bin HU Xiaomin Q IU Ting WANG Yu FAN Li MA Jun CHEN Sen WEI Zhigang LI Hongyu LIU Haisu WAN Zhihao WU Qinghua ZHOU 

机构地区：[1]Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University Hospital,Tianjin 300052, China

出　　处：《中国肺癌杂志》2009年第6期515-517,共3页Chinese Journal of Lung Cancer

基　　金：supported by a grant from the key project of the National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30430300);National Natural Science Foundation of China (to Qinghua ZHOU)(No. 30670922);INTERNATION Scienc and Techniquie COOPRATION PROGRAM OF CHINA (ISCP) (to Qinghua ZHOU)(No.2006DFB32330)

摘　　要：Background and Objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. To study and elucidate the molecular mechanismBackground and Objective Invasion and metastasis is not only the malignant phenotypes of lung cancer but also the main cause of death. To study and elucidate the molecular mechanism of lung cancer invasion and metastasis is very important. Nm23-H 1 was originally identified as a tumor metastasis suppressor gene; its functional and structural abnormality was closely correlated with the invasion and metastasis of cancer. Our previous research results have proven that the reduced expression and hetero-deletion of nrn23-H1 gene have been proved to be closely correlated with the high metastasis potential and poor prognosis of lung cancer. Transfection of the wild type nm23-H1 gene can reverse the malignant and metastatic phenotype of the human lung cancer cell line L9981. Although lots of work have been done, little is known about the exact molecular mechanisms. Sitedirected mutant technique can correctly change the base sequence and get mutant proteins, so as to explore the relationship between the functional and structural change of genes. In order to explore the association between the biochemical activity and function on suppressing the tumor metastasis,

关 键 词：NM23-H1 肺癌 治疗 疗效 

分 类 号：R734.2[医药卫生—肿瘤]