己烯雌酚对肿瘤生长、转移的影响及机制探讨  

Effect of diethylstibestrol on tumor growth metastasis and its mechanism analysis

作　　者：邓松华[1,2] 汪思应[1,2] 程洁[1,2] 张宝霆[1,2] 姚立人[1,2] 王丹[1,2] 

机构地区：[1]安徽医科大学病生教研室 [2]安徽省立医院

出　　处：《临床与实验病理学杂志》1998年第3期279-281,共3页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金

摘　　要：目的：研究己烯雌酚（ＤＥＳ）对实验性肿瘤转移的影响。方法：利用自发性Ｌｅｗｉｓ肺癌（ＬＬＣ）及实验性Ｂ１６黑色素瘤（Ｂ１６Ｍ）转移模型研究ＤＥＳ对肿瘤生长、转移的影响。结果：发现预先用ＤＥＳ处理的小鼠对其移植的ＬＬＣ生长和自发性肺转移均有抑制作用，且ＤＥＳ剂量与肿瘤的生长、转移呈直线负相关（ｒ＞０．８０，Ｐ＜０．０１）；Ｂ１６Ｍ实验性肺转移也明显减少；小鼠接种ＬＬＣ后给予ＤＥＳ对ＬＬＣ也有抑制作用。经ＤＥＳ处理后小鼠巨噬细胞吞噬功能及淋巴细胞转化功能增强，但ＮＫ细胞活性降低。Purpose To study the effect of endocrine on tumor growth and metastasis. Methods The effect of diethylstibestrol(DES) on tumor was studied using Lewis Lung Cancer (LLC) spontaneous and B16 meleoma (B16M) expermental metastatic model. Results It was found that the mice treated with DES preliminarily showed inhibitory function on the growth and spontaneous metastasis of transplanted LLC, and DES was dose dependently and negatively corrolative with the tumor growth and metastasis (r>080,P<001). It was showed inhibitory function on B16M expermental pulmonary metastasis, too. If DES was given after they were innocutated LLC, the mice demonstrated inhabitory effect. The phagocytosis of macrophage and conversion of lymphocytes increased and NK activity decreased after the mice were treated with DES. Conclusion The comprehensive effect of DES on immune function may be one of important mechanisms against tumor.

关 键 词：己烯雌酚 巨噬细胞 肿瘤转移 实验 

分 类 号：R73－361[医药卫生—肿瘤] R977.12[医药卫生—临床医学]