进口大剂量顺铂耳毒性的临床分析  

Clinical Analysis of High-Dose Cisplatin Ototoxicity

作　　者：庄晓文[1] 林英城[1] 林雯[1] 方庆动[2] 

机构地区：[1]汕头大学医学院附属肿瘤医院内科 [2]广东汕头市中心医院耳功能室

出　　处：《汕头大学医学院学报》1998年第2期18-19,共2页Journal of Shantou University Medical College

摘　　要：目的：了解大剂量顺铂的耳毒性。方法：应用含进口大剂量顺铂的联合化疗方案治疗患者21例,测定其治疗前后的气导纯音听力阈。结果：顺铂耳毒性表现：第1周期治疗后为高频失听（6000、8000Hz）,第2周期治疗后向3000、4000Hz等频率发展,程度加重。To leam high-dose cisplatin ototoxicity. Methal: 21 patients were treated by chemotherapeutic regimens including high - dose cisplatin to test air-conduction auditory threshold before and after therapy. Result: High frequencyhearing loss 6000, 8000Hz was observed after the first cycle therapy, and 3000, 4000Hz after the second cycle therapy, suggesing exacerbation.

关 键 词：顺铂 耳毒性 药物疗法 剂量 

分 类 号：R730.53[医药卫生—肿瘤] R764.02[医药卫生—临床医学]