超氧化物歧化酶抗辐射作用的Ⅱ期临床观察  

The second phase clinical observation of anti-radiation effect by SOD

作　　者：涂青松[1] 唐建兵[1] 申良方[1] 雷衍凡[1] 于顺江[2] 周觉初[2] 何家琳[2] 陈春岳[2] 张福泉[2] 张凤英 董峰 彭辉 谭华 

机构地区：[1]湖南医科大学附属湘雅医院放射治疗科 [2]北京协和医院 [3]长沙生化药厂

出　　处：《湖南医科大学学报》1998年第3期308-310,共3页Bulletin of Hunan Medical University

摘　　要：在１５９例恶性肿瘤接受放疗的病人中，进行多中心随机对照双盲肌注ＳＯＤ注射剂，评估其预防对抗放疗不良反应效果的临床价值。注射ＳＯＤ使患者放疗后的皮肤、口腔粘膜、腹盆腔脏器乃至全身重度反应的发生率明显低于安慰剂对照组，且未见任何副作用。提示ＳＯＤ是一种安全有效的减轻放疗反应的制剂。Multiple center randomized controlled double blind clinical trait was conducted to evaluate the anti-radiotherapy effect by SOD (produced by Hunan Biochemical Work) in 159 patients. Injection of 4000U SOD immediately after receiving radiotherapy significantly reduced the occurence rate of skin, oral mucosal, pelvic visceral and systematic adverse reaction, only the reduction of leukopenia did not reach the statistical significant level. No adverse effect of SOD injection was observed. The results suggest that SOD is a safe and effective agent to atenuate the radiotherapy reactions.

关 键 词：超氧化物歧化酶 肿瘤 放射疗法 副作用 预防 

分 类 号：R730.55[医药卫生—肿瘤] R969.4[医药卫生—临床医学]