白血病继发网硬蛋白纤维化的骨髓活检研究  

Study on Bone Marrow Biopsy of Leukemia with Reticulin Myelofibrosis

作　　者：张启国[1] 浦权[1] 杨梅如[1] 陶英[1] 刘薏芝[1] 

机构地区：[1]上海市第六人民医院血液科,200233

出　　处：《临床血液学杂志》1998年第4期158-160,共3页Journal of Clinical Hematology

摘　　要：目的：评估骨髓活检在急、慢性白血病继发网硬蛋白纤维化时的诊断价值。方法：对比分析76例急、慢性白血病继发网硬蛋白纤维化的骨髓切片与涂片诊断结果，动态观察10例急非淋患者化疗过程中网硬蛋白纤维量的变化情况。结果：网硬蛋白纤维可致白血病患者骨髓涂片假性增生减低并引起误诊，活检可起修正作用。伴骨髓纤维化的早期白血病切片能比涂片更早作出诊断。网硬蛋白纤维量的变化与白血病化疗疗效有关。结论：骨髓切片与徐片起互补作用，诊断急慢性白血病须把二者结合起来分析。Objective:To explore the value of bone marrow biopsy in diagnosing acute and chronic leukemia with reticulin myelofibrosis. Methods: We compared the diagnose of trephine biopsy with that of aspiration in 76 patients. The level of reticulin fiber was also monitered during chemical therapy in 10 AML patients. Results:Reticulin myelofibrosis led to psedohypoplastic leukemia in bone marrow smear.Trephine biopsy could correct some mistakes diagnosed only by bone marrow smear. Trephine biopsy showed the change earlier than aspirtionin in the early leukemia with reticulin myelofibrosis. The level of reticulin fiber was related tochemotherapeutical effects. Conclusion:The diagnose of acute and chronic leukemiawith myelofibrosis should combine bone marrow smear with trephine biopsy.

关 键 词：白血病 急性 慢性 网硬蛋白纤维 骨髓活检 

分 类 号：R733.7[医药卫生—肿瘤]