老年肺癌患者雌、孕激素受体测定的临床评价  

Clinical Significance of Estrogen and Progesterone Receptors in Aged Lung Cancer

作　　者：朱晓莉[1] 李基业[1] 张祖贻[1] 

机构地区：[1]南京铁道医学院附属医院呼吸内科

出　　处：《南京铁道医学院学报》1998年第2期112-113,共2页Journal of Nanjing Railway Medical College

摘　　要：目的：研究老年肺癌患者雌、孕激素受体表达的临床意义。方法：用免疫组化法（ＡＢＣ法）检测２５例老年肺癌组织、６例正常肺组织、５例肺良性病变组织（对照组）纤支镜活检标本的雌激素受体（ＥＲ）和孕激素受体（ＰＲ），并试用三苯氧胺对其中１０例肺癌患者行内分泌治疗。结果：老年肺癌患者的ＥＲ阳性率为６４％（１６／２５），ＰＲ阳性率为３６％（９／２５），而对照组未发现ＥＲ和ＰＲ，且三苯氧胺对老年肺癌患者有效。结论：部分老年肺癌患者组织中存在着ＥＲ、ＰＲ，其测定为选择性应用内分泌疗法治疗肺癌提供了理论依据。Objective:The aim of the article is to investigate the clinical significance of estrogen and progesterone receptors expression in the age's patients,suffering lung cancer.Methods:25 old ages' patients suffering from lung cancer and 6 normal lung persons and 5 benign lung disorder patients were examined for estrogen and progesterone receptors by using immunohistochemical method(ABC) in paraffin-embedded tissues.Results:The positive rates of ER and PR in the ages' lung cancer tissue were 64%(16/25) and 36%(9/25),however,with no ER and PR in control group.Tamoxifen is effective on lung cancer,especially on those ER and PR positive.Conclusion:The presence of ER and PR in the ages' lung cancer cells may provide a basis for adjuvant endocrine therapy in the selected lung cancer tissues.

关 键 词：肺癌 雌激素受体 孕激素受体 三苯氧胺 老年人 

分 类 号：R734.203[医药卫生—肿瘤]