术后辅助化疗时间对Ⅲ期和高危Ⅱ期结直肠癌3年无病生存期的影响  

Impact of adjuvant chemotherapy duration on 3-year disease-free survival of colorectal carcinoma patients after radical resection

作　　者：邱妙珍[1,2] 滕开原[1,2] 阮丹云[1,2] 李宇红[1,2] 陈晓勤[1,2] 潘志忠[1,3] 何友兼[1,2] 万德森[1,3] 徐瑞华[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心内科,广东广州510060 [3]中山大学肿瘤防治中心腹科,广东广州510060

出　　处：《癌症》2009年第7期743-748,共6页Chinese Journal of Cancer

摘　　要：背景与目的:Ⅲ期和高危Ⅱ期结直肠癌患者术后接受辅助化疗已得到越来越多临床医生的认可,但在临床实践中我们发现只有部分患者最终完成半年的辅助化疗,本研究的目的是分析我院Ⅲ期和高危Ⅱ期结直肠癌患者术后辅助化疗的时间,探讨结直肠癌术后辅助化疗时间对3年无病生存期的影响。方法:收集并分析2003年7月至2007年12月间在中山大学肿瘤防治中心确诊的Ⅲ期和高危Ⅱ期结直肠癌患者276例,所有患者均接受了根治性手术,术后接受了含有5-FU/CF或希罗达或替加氟±奥沙利铂方案化疗至少2疗程。结果:276例患者中有216例接受含有奥沙利铂方案的化疗,另外60例接受希罗达或5-FU/CF或替加氟的化疗。216例患者中只有49例(22.7%)最终完成了半年的辅助化疗。单因素和多因素分析均显示术后辅助化疗时间、年龄、性别、淋巴结N分期、病理分化程度是影响3年无病生存期的独立因素(P<0.05)。结论:结直肠癌患者术后辅助化疗时间是3年无病生存期的独立影响因素。Background and Objective： Adjuvant chemotherapy has become a standard postoperative treatment for stage Ⅲ and high risk stage Ⅱ colorectal carcinoma patients. However, only a few patients can finish 6-month adjuvant chemotherapy. This study was to find out whether the duration of adjuvant chemotherapy would affect the 3-year disease-free survival. Methods： Clinical data of 276 colorectal carcinoma patients, receiving at least two cycles of adjuvant chemotherapy including xeloda, 5-fluorouracil/calcium folinate （5-FU/ CF） or Tegafur with or without oxaliplatin after radical operation in Sun Yat-sen University Cancer Center from April, 2003 to December, 2007, were analyzed for the impact of adjuvant chemotherapy duration on the 3-year disease-free survival. Results： Of the 276 patients, 216 received chemotherapy including oxaliplatin, 60 received xeloda, 5-FU/CF or tegafur as adjuvant chemotherapy. Of the 216 patients, only 49 finished the 6-month adjuvant chemotherapy. Both univariate and multivariate analyses showed that chemotherapy duration （P= 0.032）, sex （P=0.001）, N stage （P=0.002）, and pathologic differentiation （P= 0.043） were independent prognosis factors for 3-year disease-free survival. Conclusion： Duration of adjuvant chemotherapy is an independent prognosis factor for 3-year disease-free survival of colorectal carcinoma patients.

关 键 词：结直肠肿瘤 辅助化疗 化疗时间 无病生存期 

分 类 号：R735.3[医药卫生—肿瘤]