缺氧诱导因子-1α:很有潜力的肿瘤治疗靶点  

Hypoxia-inducible factor-1α: a promising target for tumor therapy

作　　者：唐彬秩[1] 赵凤艳[1] 屈艺[1] 母得志[1] 

机构地区：[1]四川大学华西第二医院儿科,四川成都610041

出　　处：《癌症》2009年第7期775-782,共8页Chinese Journal of Cancer

基　　金：国家自然科学基金项目(No.30570623)~~

摘　　要：缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)是在缺氧条件下广泛存在于人类和哺乳动物细胞内的一种核转录因子,对维持体内氧稳态起重要的调节作用。缺氧是实体肿瘤内部的常见现象,缺氧应激引起HIF-1α的聚集、活化,活化的HIF-1α通过与相应的靶基因序列结合调控多种缺氧反应基因的表达,以维持肿瘤细胞的自身氧稳态及能量代谢平衡,在肿瘤的发生发展中起着极为重要的作用。目前,对HIF-1α的研究已经成为肿瘤学研究中一个令人关注的领域,相关研究成果进一步加深了科学工作者对HIF-1α在肿瘤生物学进程中的作用及其信号通路调控的认识,为寻求肿瘤治疗的新靶点提供了重要科学依据和新思路。EAbstractl Hypoxia-inducible factor-1α （HIF-1α）, a nuclear transcriptional factor, is constitutively expressed in mammalian cells under hypoxia, which contributes a 1α to the regulation of internal 02 homeostasis. Microenvironmental hypoxia is a common feature of solid tumors. Under the stress of hypoxia, HIF-1α is accumulated and activated, which leads to activation of a vast array of downstream genes that contribute to tumor O2 homeostasis and energy metabolic equilibrium. HIF-1α weighs heavily in favor of tumor genesis and progression. So far, HIF-1α has became an attracting tumor research topic, which improves understanding on how HIF-1α functions in tumor progression and key signaling pathways that regulate HIF-1α, therefore, provides new scientific supports and ideas to look for novel target for tumor therapy.

关 键 词：缺氧诱导因子-1Α 肿瘤 生物学行为 信号通路 治疗靶点 

分 类 号：R730.5[医药卫生—肿瘤]