高脂喂养大鼠内脏脂肪组织C反应蛋白的表达  

Expression of C-reactive protein in visceral adipose tissue of rat with high fat diet

作　　者：代玲俐[1] 李晓永[1] 林宁[1] 董艳[1] 苏青[1] 

机构地区：[1]上海交通大学医学院附属新华医院内分泌科,200092

出　　处：《中华内分泌代谢杂志》2009年第3期323-325,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：高脂饲料喂养10周的SD肥胖大鼠腹部内脏脂肪含量明显高于对照组[（26±6vs13±3）g，P〈0．01]，高脂组大鼠腹部内脏脂肪中C反应蛋白（CRP）mRNA水平较对照组高（0．901±0．085vs0．402±0．036，P〈0．01），高脂组门静脉[（743．8±95．8vs558．3±118．3）mg／L，P〈0．01]和外周静脉血清CRP浓度[（596．3±38．9vs485．8±30．2）mg／L，P〈0．05]均高于对照组。高脂组门静脉血清CRP浓度显著高于外周静脉（P〈0．01），但对照组差异无统计学意义。提示腹部内脏脂肪产生的CRP可能是肥胖者循环CRP的重要来源之一。The abdominal visceral fat content in obese SD rats induced by high fat diet for 10 weeks was significantly higher than that in control group [ （26 ±6 vs 13±3 ）g, P〈0.01 ], along with increased C RP mRNA expression in abdominal visceral fat （0.901 ±0. 085 vs 0. 402±0. 036, P〈0.01 ）. As compared with normal control group,in the high fat group the concentrations of CRP in portal vein [ （743.8±95.8 vs 558.3 ±118.3 ）mg/L, P〈 0.01 ] and peripheral vein [ （ 596.3±38.9 vs 485.8 ±30.2 ） rag/L, P〈0.05 ] were higher. The concentration of CRP in portal vein was significantly higher than that in peripheral vein in high fat diet group（ P〈0.01 ） ,but this was not evident in control group. These results suggest that the increased CRP expression in visceral adipose tissue may partially account for the elevation of serum CRP in obesity.

关 键 词：C反应蛋白 肥胖 脂肪组织 高脂饮食 

分 类 号：R589.2[医药卫生—内分泌] R-332[医药卫生—内科学]