食管癌患者血清胃液脑肠肽变化意义  

Alterations of the peptides of sera and gastric juice in patients with esophageal cancer

作　　者：许昌泰[1,2] 闫小君[1,2] 王奕 张仲才[1,2] 潘伯荣 

机构地区：[1]第四军医大学全军基因诊断技术研究所 [2]解放军473医院内二科

出　　处：《华人消化杂志》1998年第6期513-515,共3页

摘　　要：目的研究食管癌患者血清胃液脑肠肽变化意义．方法用放射免疫法测定２５例中晚期食管癌患者血清胃液中物质Ｐ（ＳＰ），β内啡肽（βＥＰ），血管活性肠肽（ＶＩＰ），胃动素（ＭＴＬ），促胃液素（ＧＴ）和亮脑啡肽（ＬＥＫ）含量，并以２７例相当的正常人作对照．结果食管癌患者血清，胃液ＳＰ（ｐｍｏｌ／Ｌ，８８０±５４７ｖｓ３８７±２０９，Ｐ＜００１；２３０±８０ｖｓ１８２±７３，Ｐ＜００５）βＥＰ（ｎｇ／Ｌ，６１７±２６４ｖｓ３６６±２０８，Ｐ＜００１；５１７±１６１ｖｓ３０３±１２０，Ｐ＜００１），胃液ＶＩＰ（ｎｇ／Ｌ，８８１±１４３ｖｓ６５９±１９８，Ｐ＜００１），ＭＴＬ（ｎｇ／Ｌ，２０４９±４２７ｖｓ１５３５±２７２，Ｐ＜００１），ＬＥＫ（ｎｇ／Ｌ，５５５±１５ｖｓ３１８±１１６，Ｐ＜００１）含量显著高于正常人，而血清胃液ＧＴ（ｎｇ／Ｌ，３６５±２３１ｖｓ６１０±２２５，Ｐ＜００１；１９±１０ｖｓ３４±２０，Ｐ＜００１）含量则显著低于正常人，且血清胃液ＳＰ，βＥＰ升高和ＧＴ降低呈正相关（Ｐ＜００５）．结论晚期食管癌患者血清?AIM Study on the peptides of sera and gastric juices in patients with esophageal cancer. METHODS Twenty five patients with advanced stage esophageal cancer, including 18 men and 7 women with a mean age of 49 1 years and 27 normal subjects as controls including 17 men and 10 women with a mean age of 47 8 years were studied. Samples of blood and gastric juice were collected at fasting state and under endoscopy respectively. Substance P(SP), beta endorphin (β EP), vasoactive intestinal peptide (VIP), motilin (MTL), gastrin (GT), and leu enkephalin (LEK) of the sera and gastric juice were measured by radioimmunoassay kit. RESULTS In the patients, SP (pmol/L, 88 0±54 7 vs 38 7±20 9, P <0 01;23 0±8 0 vs 18 2±7 3, P <0 05) and β EP(ng/L, 61 7±26 4 vs 36 6±20 8, P <0 01;51 7±16 1 vs 30 3±12 0, P <0 01) of serum and gastric juice, and VIP (ng/L, 88 1±14 3 vs 65 9±19 8, P <0 01), MTL(ng/L, 204 9±42 7 vs 153 5±27 2, P <0 01) and LEK (ng/L, 55 5±15 vs 31 8±11 6, P <0 01) of gastric juice, were higher than those in the normal subjects, and gastrin (ng/L, 36 5±23 1 vs 61 0±22 5, P <0 01;1 9±1 0 vs 3 4±2 0, P <0 01) of serum and gastric juice were decreased. Serum and gastric juice SP, β EP levels correlated negatively with the gastrin ( r =0 449-0 473, P <0 05). CONCLUSION The peptides of serum and gastric juice have significant changes in esophageal cancer patients clinically.

关 键 词：食管肿瘤 诊断 Β内啡肽 血管活性肠肽 

分 类 号：R735.102[医药卫生—肿瘤]