残胃粘膜细胞形态和DNA含量变化的研究  

Study the Changes of Cytomorphoetry and DNA Content in the Gastric Stump

作　　者：张文远[1] 王崇文[2] 徐家瑞 

机构地区：[1]四川省人民医院消化科,成都610072 [2]江西医学院第一附院消化科

出　　处：《临床消化病杂志》1998年第2期52-55,共4页Chinese Journal of Clinical Gastroenterology

摘　　要：应用全自动图像分析仪对正常胃粘膜、残胃粘膜术后0～5年、6～10年及10年以上重度异型增生和胃癌进行了细胞形态、DNA含量和倍体分布测定.结果发现:残胃粘膜随术后时间的延长,其细胞形态、DNA含量和倍体分布也发生相应变化.以术后10年以上残胃粘膜变化较为显著.和真正的癌前病变—重度异型增生比较,DNA含量、倍体分布均无显著性差异.和胃癌比较:已具有癌细胞的一些病理特征.作者认为:凡残胃粘膜出现了异型增生、DNA含量增高和多倍体细胞,应警惕癌变的可能.Cytomorphometry, DNA content and ploidy pattern was made on epithelial cells from 54 cases of normal gastric mucosa, the gastric stump (post-operation 0～5 years, 6～10 years, > 10 years), dysplasia(severe) and carcinoma of stomach with the instrument of image analysis system (IBAS). The result showed that with the period of post-operation following up continue the cytomorphometry, DNA content and ploidy pattern gradually changed, the changes were more significant in the gastric stump of post-operation over 10 years. There was no markable difference between the gastric stump (Post-operation> 10 years) and dysplasia (severe) in DNA content and ploidy pattern. Some character of cancinoma in pathology had also been shown in the gastric stump (post-operation over 10 years) . In author's opirion, an early cancinoma maybe existed if there are severe dysplasia higher DNA content and multic ploidy pattern ( >5C) in the gastric stump.

关 键 词：细胞形态 DNA 残胃 异型增生 胃癌 

分 类 号：R735.202[医药卫生—肿瘤]