MTT法体外药敏试验在46例胃癌术后化疗中的应用  

Application of Chemosensitivity Testing of MTT to Chemotherapy for 46 Cases of Patients after Operation

作　　者：陈少华[1] 刘小朋[1] 张国安[1] 叶爱珍[1] 饶本强[2] 

机构地区：[1]中国人民解放军476医院 [2]南京军区福州总医院

出　　处：《福建医药杂志》1998年第3期113-114,161,共2页Fujian Medical Journal

摘　　要：应用MTT法检测46例胃癌手术切除标本对8种常用的化疗药物的体外敏感性，探讨此方法作为胃癌术后化疗用药依据的可靠性。结果表明：不同个体胃癌对同种化疗药物的敏感性不同，其中以羟基喜树碱、顺铂等敏感性较高。根据试验结果选择药物行术后化疗，随访1、2年生存率分别为94．7％（36／38）、79．2％（19／24）。结论：提示此药敏试验对胃癌术后辅助化疗方案的选择有指导意义。The sensitivity in 46 samples of gastric cancer to eight normal different types of antitumor drugs was in vitro assayed by MTT, to evaluate the reliability of using those drugs for the patients. The result indicated that gastric cancer sensitivity to antitumor drugs was individual. And among the eight types of drug HPT and DDP were more sensitivity than rest of them. On the base of testing results, selected drugs for chemotherapy for the patients after operation were applied with the living rate of 94. 7％ (36／38) and 79. 2％ (19／24) respectively in patients following up one and two years. it concluded that MTT assay for antitumor drug was condusive to selection of chemotherapy for patient,after operation.

关 键 词：胃肿瘤 手术后 药物疗法 药敏试验 MTT法 

分 类 号：R735.205[医药卫生—肿瘤] R969.4[医药卫生—临床医学]