血清雌激素与肝细胞癌转移的关系  

Relationship between serum estradiol and metastasis of hepatocellular carcinoma

作　　者：郑世曦[1,2,3] 陈汉琴[1,2,3] 王先松 杨军[1,2,3] 阮幼冰 武忠弼 

机构地区：[1]中国科学院上海药物研究所博士后流动站药理一室 [2]同济医科大学实验医学研究中心超微病理研究室 [3]武汉市职工医学院附属医院

出　　处：《华人消化杂志》1998年第6期482-483,共2页

摘　　要：目的了解血清雌激素升高与原发性肝细胞癌（ＨＣＣ）转移的关系．方法应用放射免疫分析法（ＲＩＡ）对ＨＣＣ患者血清雌二醇（Ｅ２）含量进行了检测，并应用原位杂交研究外源性Ｅ２对肝癌细胞系ＣＢＲＨ７９１９血管内皮生长因子（ＶＥＧＦ）和层粘蛋白受体（ＬＮＲ）表达的影响．结果ＨＣＣ患者血清Ｅ２水平较正常者显著升高，且ＨＣＣ有转移者血清Ｅ２水平较无转移者亦显著升高；原位杂交结果显示，外源性Ｅ２能够增加ＣＢＲＨ７９１９细胞表达ＶＥＧＦ和ＬＮＲｍＲＮＡ．结论血清Ｅ２水平增高与ＨＣＣ转移密切相关，它有可能通过促进ＶＥＧＦ和ＬＮＲ的合成而影响肿瘤的转移过程．AIM To understand the relationship between elevated serum estradiol (E 2) and the metastasis of hepatocellular carcinoma (HCC). METHODS Radioimmunoassay (RIA) was used to measure serum E 2 level in patients with HCC. In situ hybridization was used to investigate vascular endothelial growth factor (VEGF) and laminin receptor (LN R) RNA expression in hepatoma cell line CBRH 7919 stimulated by extragenous estradiol. RESULTS Elevated serum E 2 concentration was found in both patients with and without metastasis. It was significantly higher in the former than that in the latter. The results of in situ hybridization showed that extragenous E 2 could stimulate both VEGF and LN R mRNA expression. CONCLUSION Elevated serum E 2 is associated with the metastasis of HCC, which may be upregulate the expression of VEGF and LN R mRNA in the tumor cells.

关 键 词：肝肿瘤 病理 雌二醇 内皮生长因子 LN-R 

分 类 号：R735.7[医药卫生—肿瘤]