氧代赖氨酸对小鼠实验性肝癌的治疗作用  

THERAPEUTIC EFFECT OF L4OXALYSINE ON MOUSE EXPERIMENTAL LIVER CANCER

作　　者：王兴旺[1] 张振德 徐永平 胥彬[1] 

机构地区：[1]中国科学院上海药物研究所

出　　处：《中国癌症杂志》1998年第2期82-84,共3页China Oncology

基　　金：国家自然科学基金

摘　　要：目的研究氧代赖氨酸（Ｌ－４－ｏｘａｌｙｓｉｎｅ，ＯＸＬ）对小鼠实验性肝癌的治疗作用。方法采用小鼠肝癌－２２（Ｈ－２２）腹水瘤皮下移植模型。结果ＯＸＬ１５０ｍｇ／ｋｇ和３００ｍｇ／ｋｇ腹腔注射共７天，对小鼠Ｈ－２２肝癌的生长有明显抑制作用，抑制率分别为３８．７％和６８．８％。ＯＸＬ３００ｍｇ／ｋｇ口服或肌肉注射共７天，也有明显的抗癌活性。同时给小鼠腹腔注射ＯＸＬ１５０ｍｇ／ｋｇ及氟尿嘧啶（５－ＦＵ）１２．５ｍｇ／ｋｇ共７天，对Ｈ－２２实体瘤生长的抑制率由单用ＯＸＬ时的３８．７％和单用５－ＦＵ时的３０．１％提高到合用时的７１．１％。ＯＸＬ３００ｍｇ／ｋｇ以不同途径给药对荷肝癌小鼠体重、免疫器官重量以及肾脏重量无明显影响；给予４００ｍｇ／ｋｇ时，体重和免疫器官重量明显减轻，但肾脏重量无明显改变。结论ＯＸＬ在体内对小鼠肝癌实体瘤的生长有一定抑制作用，不同给药途径抑瘤率相似。URPOSE To investigate the therapeutic effect of L4oxalysine (OXL) on mouse experimental liver cancer.METHODS A solid mouse hepatoma22(H22) model was used in vivo experiments.RESULTS An obvious suppression on growth of solid H22 tumor was found when tumorbearing mice were treated with OXL either intraperitoneally,intragastrically or intramuscularly at 300 mg/kg for 7d. When OXL 150 mg/kg was used intraperitoneally in combination with 5FU 12.5 mg/kg, the antihepatoma activity was markedly enhanced. OXL at 300 mg/kg had no significant influence on body weight and organ weight of mice bearing solid H22.CONCLUSION OXL in vivo inhibited the growth of solid mouse liver cancer.

关 键 词：氧代赖氨酸 肝肿瘤 药物疗法 

分 类 号：R735.705[医药卫生—肿瘤]