雄激素受体与肝细胞肝癌预后的关系  

ANDROGEN RECEPTOR AS A PROGNOSTIC FACTOR OF HEPATOCELLULAR CARCINOMA

作　　者：贺青卿[1,2] 杨金镛[1,2] 吴力群[1,2] 崔自介[1,2] 

机构地区：[1]济南军区总医院普外科 [2]青岛医学院附属医院

出　　处：《中国癌症杂志》1998年第2期100-101,共2页China Oncology

摘　　要：目的探讨雄激素受体（ＡＲ）与肝细胞肝癌（ＨＣＣ）预后的关系。方法用葡聚糖包裹活性炭饱和吸附法检测４７例ＨＣＣ癌组织和癌旁肝组织中ＡＲ的含量。对４３例病人进行术后随访９～６０个月。结果３３例ＡＲ阳性（３．０～１００ｆｍｏｌ／ｍｇ蛋白），１４例ＡＲ阴性。ＡＲ阳性病人与ＡＲ阴性病人的一、五年存活率没有统计学差别，三年存活率ＡＲ阳性者（３５．５％）显著低于ＡＲ阴性者（６６．７％）。复发时间ＡＲ阳性者（２１．４±１５．２月）与ＡＲ阴性者（３３．９±１３．９月）有显著差异（Ｐ＜０．０５）。结论雄激素能促进ＨＣＣ的增长及周围组织的侵袭，部分ＨＣＣ具有雄激素依赖性。URPOSE Study of androgen receptor (AR) in hepatocellular carcinoma (HCC) as a prognostic factor after hepatic resection.METHODS AR in the cytosol of HCC were assayed by dextrancoated charcoal methods in 47 patients in whom radical hepatic resection was performed.43 patients were followed up for 9～60 months.RESULTS 33 patients had detectable amounts of ARs (ranging from 30 to 100 fmol/mg protein).The receptor was not found in 14 cases.The 1year and 5year survival rates in the AR positive and AR negative groups were not statistically significant (P>005).The 3year survival rate was significantly better (P<005)in the AR negative group (667%) than that of AR positive group (355%).There was a significant difference in the recurrence time between patients with AR negative HCCs (339±139months) and those with AR positive tumors (214±152months)CONCLUSION Testosterone enhances the growth and invasiveness of human HCC,which is mediated by AR in the tumor.AR acts as a prognostic factor after hepatic resection.

关 键 词：肝肿瘤 雄激素 受体 预后 

分 类 号：R735.707[医药卫生—肿瘤]