NT-海球栓对肾癌侧肾动脉栓塞的病理研究  

Pathological Observation on the RenalArterioembolization with Kidney Cancer with NitinolArterioembolizer in Conical and Rugby Spiral Forms (NT - CRE)

作　　者：陶文照[1] 郑唯强[1] 王飞[2] 张春才[2] 张维娥[2] 秦桂英[3] 

机构地区：[1]第二军医大学病理学教研室,200433 [2]第二军医大学附属长海医院 [3]上海钢铁研究所

出　　处：《交通医学》1998年第3期273-275,共3页Medical Journal of Communications

摘　　要：作者应用海螺状与螺旋球形记忆合金血管栓塞器(简称NT-海球栓)对肾癌侧肾动脉进行栓塞。对7例手术切除的肾癌标本进行巨检和光镜观察,结果显示:(1)4例靶肾动脉的改变,主要发生在NT-海球栓的扩卡部,该栓塞段动脉壁呈扩张状态,因NT-海球栓的机械压迫致内皮细胞萎缩变性或坏死,内弹性腆断裂或消失。中膜内干滑肌细胞萎缩变性,其弹性纤维断裂和减少。外膜无明显改变。有2例附加明胶海绵栓塞剂,在肾动脉内有血栓形成,伴有动脉炎;(2)7例靶肾癌组织的改变:肾组织主要显示缺血性萎缩变性坏死,其变性的严重程度依次是:近曲小管、远曲小管、肾小体。有5例发生1～2处梗死灶。靶肾癌组织大部分发生坏死。残存的癌组织部分存活、部分变性。Pathological observations with gross and light microscopes were performed on the 7 cases postoperative kidney cancer whose aiteria had been embolized with Nitinol Arterioembolizer in Conical and Rugby Spiral Forms (NT- CRE) from the Research Laboratory of Biofunctional Materials Changhai Hospital and Shanghai Iron & Steel Institute.The Changes of the target arteries were mainly due to the compression of NT- CRE.Leading to atrophy or necrosis of endothelial cells and the intenal elastic membrane broke off disappeared.and also in medium membrane.But there was no obvious changes in adven-titia membrane.The arteritis could be found in 2 case used by embolizer gelatin sponge.There were apparent area of is-chemic atrophy and necrosis in the 7 target kidneys. 5 cases producend one - two area infarctus foci ;Most target renal cancer tissue were necrosis.The renal tissue degenerative and necrotic degree was as following in order:the proximal tubules. the distal tubules and glomeruli.The therapeutic embolization of the bigger kidney cancers had been employed before opreations showed that NT- CRE could reduce bleeding;remove tumours better:possibleby stop the cancer spread.

关 键 词：动脉栓塞器 肾癌 NT-海球栓 肾动脉栓塞 治疗 

分 类 号：R737.110.2[医药卫生—肿瘤]