伴神经内分泌分化的乳腺癌——附4例报道  

NEUROENDOCRINE DIFFERENTIATION IN CARCINOMAS OF THE BREAST:A STUDY OF 4 CASES

作　　者：徐如君[1,2] 吴能定[1,2] 戴晓汶 沈宝珠 

机构地区：[1]杭州市第一人民医院病理科 [2]解放军117医院病理科

出　　处：《中国癌症杂志》1998年第2期121-123,共3页China Oncology

摘　　要：目的探讨伴神经内分泌分化的乳腺癌的病理组织学类型及特征。方法应用免疫组化方法及Ｇｒｉｍｅｌｉｕｓ嗜银染色，确认神经内分泌分化细胞，并进行组织学观察。结果伴神经内分泌分化的乳腺癌在光镜下可有５种不同的组织学形态，本组４例免疫组化结果ＮＳＥ和Ｓｙ全部阳性，ＣＨＧ－Ａ３例阳性。嗜银染色３例阳性。结论乳腺癌伴有神经内分泌分化是肿瘤异质性的表现，是乳腺癌的一种特殊类型。URPOSE To study the pathological classification and specific fectures of neuroendocrine differentiation in carcinomas of the breast.METHODS Immunohistochemical technique and argyrophlia staining with Grimelius method were studied.All cases were studied at the histological level.RESULTS Neuroendocrine differentiation in carcinomas of the breast has five kinds different pathohistologic structure.In four cases.the immunohistochemistry for NSE and Syn were all positive.The Grimelius argyrophilia staining showed three cases to be positive.CONCLUSION Neuroendocrine differentiation in carcinomas of the breast was a specific type of the breast carcinoma.These tumors have a particular pathohistologic structure.

关 键 词：乳腺癌 神经内分泌 免疫组化 病理形态 

分 类 号：R737.902[医药卫生—肿瘤]