乳果糖对肝硬化自发性腹膜炎患者肠黏膜屏障功能的影响  

The Clinical Effect of Lactulose on Intestinal Barrier Function in Cirrhosis Patients with Spontaneous Bacterial Peritonitis

作　　者：黄宏春[1] 王秀敏[1] 王永亮[1] 李继昌[2] 

机构地区：[1]河南省安阳市人民医院消化内科,河南安阳455000 [2]郑州大学第一附属医院消化内科,河南郑州450052

出　　处：《中国临床医学》2009年第3期372-373,共2页Chinese Journal of Clinical Medicine

摘　　要：目的:探讨乳果糖对肝炎肝硬化自发性细菌性腹膜炎(SBP)患者肠黏膜屏障功能的影响。方法:将54例肝炎肝硬化SBP患者随机分为标准治疗对照组和乳果糖治疗组。检测SBP患者乳果糖治疗前后对照组及健康组均口服糖分子探针乳果糖、甘露醇,采用高压液相色谱-示差法,评估患者肠黏膜屏障功能。结果:治疗前肝硬化SBP、无菌性腹水(SA)组尿LAC/MAN均显著高于健康对照组(均P<0.001)。治疗1周后乳果糖治疗组尿LAC/MAN较对照组下降明显(P<0.01)。结论:(1)肝炎肝硬化SBP患者存在肠黏膜屏障功能异常;(2)乳果糖短期治疗可以显著改善肝炎肝硬化SBP患者肠黏膜屏障功能。Objective：To evaluate the effects of Lactulose on intestinal barrier function in hepatitis cirrhotic patients with spontaneous bacterial peritonitis （SBP）. Methods： Fitly-four SBP patients of hepatitis cirrhosis were randomized into two groups： lactulose trear,ent groupand a control group,All cases were observed for 7days. To evaluate intestinal permeability, the concentration of lactulose and mannitol in urine was measured using high-pressure liquid chromatograph with refractive index detec tor （HPLC-RID）, and the levels of urinary excretion of LAC/MAN ratios were calculated. Results： The levels of urinary excretion of LAC/MAN ratios were significantly higher in cirrhotic patients with SBP than those in SA group and healthy control group （P〈0. 001）. After treated for one week, the levels of urinary excretion of LAC/MAN ratios were significantly decreased in treating group than those in control group（P%O. 01）. Conelusion..The intestinal barrier function in hepatitis cirrhosis patients is abnormality. Oral lactulose is beneficial to intestinal barrier function in hepatitis cirrhotic patients with SBP.

关 键 词：肝硬化 自发性腹膜炎 乳果糖 肠黏膜屏障 

分 类 号：R572.2[医药卫生—消化系统]