幽门螺杆菌感染对十二指肠球部溃疡患者血清IL-6、IL-8及NO的影响  

Influence of Helicobacter pylori infection on serum IL-6,IL-8 and NO in duodenal ulcer patients

作　　者：王光余[1] 黄晓辉[1] 吴国平[1] 

机构地区：[1]海南医学院附属医院急诊内科,海南海口570102

出　　处：《海南医学院学报》2009年第8期861-863,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020090081)~~

摘　　要：目的:探讨幽门螺杆菌(Hp)感染对十二指肠球部溃疡患者血清白细胞介素6、8(IL-6、IL-8)及一氧化氮(NO)的影响。方法:分别采用双抗体夹心ELISA法和硝酸还原酶法检测40例Hp感染的十二指肠球部溃疡患者(根除Hp组和未根除Hp组)治疗前、后和10例正常对照组血清中IL-6、IL-8及NO水平的变化,并进行比较。结果:治疗2周后根除Hp组血清IL-6、IL-8及NO水平高于正常对照组,但差异无统计学意义(P>0.05),未根除Hp组血清IL-6、IL-8及NO水平明显高于正常对照组,差异有统计学意义(P<0.01);根除Hp组治疗后IL-6、IL-8及NO水平较治疗前均有显著下降(P<0.01),而未根除Hp组治疗后IL-6、IL-8及NO水平较治疗前也均有下降,但差异无统计学意义(P>0.05);与未根除Hp组比较,根除Hp组治疗后IL-6、IL-8及NO均有显著下降(P<0.01)。结论:Hp感染的十二指肠球部溃疡存在不同程度炎症,而且Hp对炎症起促进作用,根除Hp对其炎症反应起到明显抑制作用。Objective： To investigate the influence of Helicobacter pylori （HP） infection on serum IL-6, IL-8 and NO in duodenal ulcer patients. Methods： Forty patients with duodenal ulcer with HP infection were divided randomly into two groups （group A and B） , HP in patients of group A and B was eradicated and was not eradicated after treatment respectively, 10 health subjects without HP infection and DU were enrolled as group C （ control group） ; double-antibody sandwich ELISA and nitrate reductase assay were employed to determine levels of serum IL-6, IL-8 and NO in patients of group A and B before and after treatment, and those in patients of group C, and comparison was done among them. Results： After treatment of 2 weeks, levels of IL-6, IL-8 and NO in group A were higher than those in group C, but the difference was not significant （P 〉 0.05 ） ; levels of IL-6, IL-8 and NO in group B were markedly higher than those in group C, and the difference was significant （ P 〈 0.01 ） ; levels of IL-6, IL-8 and NO in group A decreased compared those with before treatment, and the difference was significant （P 〈0.01 ） ; levels of IL-6, IL-8 and NO in group B decreased compared those with before treatment, and the difference was not significant （ P 〉 0.05 ） ; compared levels of IL-6, IL-8 and NO after treatment between group A and B, which decreased significantly in group A （P 〈 0.01 ）. Conclusion： Patients with DU and HP have inflammation by variou degrees, and HP may deteriorate inflammation, and eradication of HP can inhibit the inflammatory reactions apparently.

关 键 词：幽门螺杆菌 十二指肠球部溃疡 白细胞介素6 白细胞介素8 一氧化氮 

分 类 号：R573.1[医药卫生—消化系统]