血浆PAF、TXB_2和6-k-PGF_(1α)检测在老年脑梗塞、高血压患者中的临床意义  

The measurement and clinical significance of the level of plasma PAF、TXB2 and 6ketoPGF1α in elderly patients with cerebral infarction and elderly patients with hypertension

作　　者：朱伟[1] 许文荣[1] 焦志军[1] 曹红翠[1] 顾可梁[1] 陆益龙[2] 陈二南[2] 李龙[2] 

机构地区：[1]镇江医学院临检教研室 [2]镇江医学院附属医院

出　　处：《临床检验杂志》1998年第4期223-226,共4页Chinese Journal of Clinical Laboratory Science

摘　　要：采用放射免疫、生物学方法测定２３例老年脑梗塞患者，２８例老年高血压患者及２０例正常对照组血浆血小板活化因子（ＰＡＦ）、血栓素Ｂ２（ＴＸＢ２）和６－酮－前列腺素Ｆ１α（６－ｋ－ＰＧＦ１α）水平。对９例老年脑梗塞患者和１４例老年高血压患者作应激状态下血浆ＰＡＦ、ＴＸＢ２和６－ｋ－ＰＧＦ１α测定。结果表明，老年脑梗塞患者血浆ＰＡＦ、ＴＸＢ２较健康对照组显著增高（Ｐ＜０．０１），老年高血压患者血浆ＴＸＢ２与健康对照组比较显著增高（Ｐ＜０．０１），但ＰＡＦ、６－ｋ－ＰＧＦ１α无显著差异（Ｐ＞０．０５）。老年脑梗塞患者应激后ＰＡＦ、ＴＸＢ２增加明显（Ｐ＜０．０１），且持续时间长。这些结果表明血浆ＰＡＦ、ＴＸＢ２和６－ｋ－ＰＧＦ１α检测对老年心脑血管疾病的诊断、治疗和预后有一定的临床价值。The level of plasma platelet activating factor(PAF),thromboxane B2(TXB2)and 6ketoprostaglandin F1α(6ketoPGF1α)in 23 elderly patients with cerebral infarction,28 elderly patients with hypertension,and 20 healthy controls was measured by RIA or bioassay.The level of plasma PAF,TXB2 and 6ketoPGF1α in 9 elderly patients with cerebral infarction and 14 elderly patients with hypertension was measured by emotional stress. The results showed that the elderly patients with cerebral infarction had higher level of plasma PAF,TXB2 than healthy controls (P<001),the elderly patients with hypertension had higher level of plasma TXB2(P<001)and no change of plasma PAF (P>005)than healthy controls.The elderly patients with cerebral infarction had higher level of plasma PAF,TXB2 (P<0.01)and lasted for a long time after emotional stress.It was suggested that the measurement of plasma PAF,TXB2 and 6ketoPGF1α may play a role in the diagnosis,therapy and prognosis of the elderly patients with cardiovascular or cerebrovascular dieases.

关 键 词：脑梗塞 高血压 PAF TXB2 6-K-PGF1Α 

分 类 号：R743.330.4[医药卫生—神经病学与精神病学] R544.104[医药卫生—临床医学]